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Rev. med. nucl. Alasbimn j ; 10(41)jul. 2008. ilus, tab, graf
Artigo em Inglês | LILACS | ID: lil-495997

RESUMO

Percutaneous transluminal coronary angioplasty associated with radioactive liquid-filled balloons has demostrated to be useful to inhibit the growth of neointimal tissue. The present study pursued optimizing the relation risk/benefit during a procedure of brachytherapy with 188Re associated to angioplasty. Since the possibility of balloon rupture exists, to increase the security during the treatment different agents such as 188Re-DTPA, 188Re-Citrate and 188Re-EC vs 188ReO4 were evaluated. Dosimetric studies using Mirdose 3, after iv injection to Wistar rats, evaluation of a number of safety requirements in order to estimate radiation dose delivered to operating personnel and absorbed doses estimated by Monte Carlo method (PENELOPE). It is a safe procedure, both for the patient and the working staff; in case of ballon rupture the use of the above mentioned radiopharmaceuticals increases its security. 188Re beta emitor achieves a local dosis, diminishing the dose in healthy tissue.


Assuntos
Animais , Ratos , Doença das Coronárias , Doença das Coronárias/radioterapia , Radioisótopos/administração & dosagem , Radioisótopos/farmacocinética , Rênio/administração & dosagem , Rênio/farmacocinética , Angioplastia Coronária com Balão , Braquiterapia/instrumentação , Distribuição Tecidual , Dosagem Radioterapêutica , Fatores de Tempo , Método de Monte Carlo , Compostos Radiofarmacêuticos/administração & dosagem , Compostos Radiofarmacêuticos/farmacocinética , Ratos Wistar
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