RESUMO
ABSTRACT Objective Metabolic syndrome (MetS) is associated with hypertension, obesity and dyslipidemia. Thus, genetic variants related with these conditions may modulate its development. We evaluated the effect of polymorphisms in the renin-angiotensin system (RAS) on metabolic syndrome risk in a cohort of Chilean subjects. Subjects and methods A total of 152 subjects, 83 with MetS (51.2 ± 9.6 years) and 69 without MetS (49.5 ± 9.3 years) of both genders were included, according to the ATP III update criteria. The rs4340 Insertion/Deletion (I/D), rs699 (T>C) and rs5186 (A>C) of the ACE, AGT and AGTR1 genes, respectively, were genotyped. Results After adjusting for age and gender, we observed the DD genotype of rs4340 associated with MetS (p = 0.02). Specifically, the DD genotype was associated with MetS risk in women (OR = 4.62, 95%CI, 1.41 – 15.04; p < 0.01). In males, the AA genotype for rs5186 variant was associated with an increased risk for developing MetS when compared with women carrying the same genotype (OR = 3.2; 95%CI, 1.03 – 9.89; p = 0.04). In subjects without MetS, DD genotype was associated with increased waist circumference (p = 0.023) while subjects with MetS carrying the rs5186 TT genotype showed higher levels of HDL-cholesterol (p = 0.031). Conclusion The present study contributes data highlighting the role for RAS polymorphisms in predisposing to metabolic syndrome in Chilean subjects.
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Polimorfismo Genético , Sistema Renina-Angiotensina/genética , Síndrome Metabólica/genética , Hipertensão/genética , Chile , Fatores Sexuais , Angiotensinogênio/genética , Estudos Transversais , Estudos de Coortes , Fatores Etários , Deleção de Genes , Peptidil Dipeptidase A/genética , Predisposição Genética para Doença , Receptor Tipo 1 de Angiotensina/genética , GenótipoRESUMO
El tumor maligno de ovario en el embarazo se encuentra en un 2 a 5 por ciento de todas las masas anexiales que ocurren en el embarazo. El embarazo no tiene un efecto adverso directo en el pronóstico de las pacientes con un tumor de ovario maligno; se requiere de una buena clasificación por estadios durante el procedimiento quirúrgico para establecer un adecuado tratamiento. Presentamos el caso de una mujer de 35 años diagnosticado y manejado en el Hospital San Rafael de Tunja. Colombia, con 20 semanas de embarazo y un tumor de ovario gigante que fue clasificado por el estudio histopatológico como cistadenocarcinoma mucinoso; se hace una revisión detallada de la literatura de tumor de ovario y embarazo