Oxifilia nas lesões nodulares da tireóide: classificação e relação com marcadores imunohistoquímicos e mutações nos genes BRAF e RAS e rearranjo PAX8-PPARy / Oxyphilia in thyroid nodules: classification and relationship with immunohistochemical markers and mutations in BRAF and RAS genes and PAX8-PPARy rearrangement

Uma série de 205 casos de lesões nodulares da tireóide foi revista morfologicamente de acordo com a nova classificação da Organização Mundial da Saúde (OMS, 2004) e analisada quanto à oxifilia e imunoexpressão das citoqueratinas 14 (CK 14) e 19 (CK19) e de citocromo-oxidase. Os carcinomas foram analisados para mutações dos genes BRAF, RAS e rearranjo PAX8-PPARγ.– mutações no RAS – mutações no BRAF – rearranjo PAX8-PPARγ...

A series of 205 thyroid nodules was morphologically reviewed according to the new World Health Organization (WHO, 2004) classification and analyzed regarding the oxyphilia and immunoexpression of cytokeratins 14 (CK14) and 19 (CK19) and cytochrome oxidase. Carcinomas were screened for BRAF and RAS mutations and PAX8-PPARγ rearrangement...

Salivary gland tumors in a Brazilian population: a retrospective study of 124 cases

Salivary gland tumors constitute a highly heterogeneous histopathologic group. There are few epidemiological studies of large series of benign and malignant salivary gland tumors in Brazil. MATERIAL AND METHODS: Hospital records of 124 patients with salivary gland tumors diagnosed from January 1993 to December 1999 were reviewed. The patients were analyzed according to gender, age, size, location, and histopathology of the tumor. RESULTS AND CONCLUSIONS: Patients with benign and malignant tumors presented with a mean age of 47.7 and 48.8 years, respectively. The frequency of benign tumors was 80 percent (n = 99) and malignant tumors 20 percent (n = 25). Tumors were localized in the parotid gland 71 percent (n = 88), in the submandibular gland 24 percent (n = 30), and in the minor salivary glands 5 percent (n = 6). The most common benign tumors were pleomorphic adenoma in 84 percent (n = 84) and Warthin's tumor in 13 percent (n = 13). Among malignant tumors, mucoepidermoid carcinoma was the most common in 52 percent (n = 13), adenoid cystic carcinoma occurred in 20 percent (n = 5), and carcinoma ex pleomorphic adenoma was detected in 12 percent (n = 3)

Cisto de paratireoide: relato de caso / Parathyroid cyst: case report

Os cistos de paratireoide säo lesöes muito raras, com cerca de 200 casos descritos na literatura. Seu principal diagnóstico diferencial e com nódulo tireodiano, podendo causar sintomalogia de compressäo cervical e hiperparatireoidismo. Descrevemos um caso em que o diagnóstico foi realizado somente no exame de congelaçäo intra-operatório e discutimos aspectos relevantes na conduta nesses tumores infrequentes