importance of serum prostate specific antigen levels in demonstration of potency between the extent and the degree of aggressiveness of inflammation in patients with asymptomatic chronic prostatitis

To compare the extent and the degree of aggressiveness of inflammation on the total prostate specific antigen [t-PSA], free PSA [f-PSA], free / t-PSA ratio, and PSAD values in patients with chronic prostatitis. Retrospective, descriptive study. Yuksek Ihtisas Training and Research Hospital, Turkey. Fifty-five patients with serum t-PSA levels higher than 4 ng / ml and with chronic prostatitis were included. Transrectal ultrasound guided biopsy was taken from patients with serum PSA levels higher than 4 ng / ml. Histological sections of the prostatic tissues were scored using the extent and aggressiveness of inflammation seen, on a four point scale from 0 to 4. Serum PSA levels in different inflammation grades were compared. Kruskal-Walls variance analysis was used for inter-group assessment. In both groups scoring; no patient was in grade O. On the extent of inflammation group scoring; 2, 36, and 17 patients had grade 1, 2, 3, respectively. In this group, unlike the t-PSA values, the extent of inflammation was significant in PSA-D [p = 0.004] with a negative correlation in f / t PSA values. On the aggressiveness of inflammation group scoring; 18, 23, and 14 patients had grade 1, 2, 3, respectively. In this group, no statistical difference was found in terms of t-PSA, but statistical differences were monitored in terms of f-PSA, f / t PSA, and PSA-D values [p = 0.03, 0.002, 0.01, respectively]. High serum PSA levels in patients with asymptomatic chronic prostatitis may correlate with the degree of extent and aggressiveness of inflammation

effect of gene polymorphisms [ENOS G894T, PON1 and catalase -262C-T] on fertility and sperm parameters in Turkish men with clinical varicocele: a pilot study

Scrotal varicocele is found to be associated with increased spermatozoal reactive oxygen species [ROS] production and decreased seminal plasma antioxidant activity. Our objective was to search for an association between male infertility and gene polymorphisms [PON1, ENOS G894T and Catalase -262C-T]. Controlled prospective study. Ataturk and Yuksek Ihtisas Education and Training Hospitals, Ankara, Turkey. Forty primary infertile men and forty healthy men were included in the study. Patients with clinical varicocele in the study group had no endocrinopathy, no surgery for varicocele / inguinal hernia, and / or no leukospermia. They were non-smokers. Doppler ultrasonography [USG] was performed for the patients. For genetic analysis, 5 ml of venous blood was drawn into tubes containing EDTA from each patient. Gene polymorphism, progressive sperm motion and vein diameter. Existence of gene polymorphisms was statistically important in patients who had clinical varicocele with affected progressive forward motion. We determined statistically significant rate of gene polymorphisms in enzymatic antioxidant defence systems in patients with clinical varicocele, with a diameter of spermatic vein above 2.2 mm and forward progressive sperm motion below 32% [p < 0.001]. These polymorphisms might represent risk factors for Turkish men with clinical varicocele and forward progressive sperm motion defect. This is a pilot study. We intend to continue these studies with larger sample sizes to confirm these findings

Comparison of changes in body image of patients with renal calculi treated by pyelolithotomy or percutaneous nephrolithotomy

To compare changes in body image of patients who had pyelolithotomy [PYL] or percutaneous nephrolithotomy [PNL] for kidney stones Prospective, descriptive study Elazig Education and Research Hospital, Turkey A total of 69 patients, who had PNL or PYL done for renal stones, were evaluated, prospectively. Patients were divided into two groups: PNL [39 patients] and PYL [30 patients]. Body dismorphic disorder scale [BDDS] was used to measure body image changes of these patients before, one and six months after the operation. The patients were questioned and their answers were noted. BDDS score was calculated according to the answers. Mean BDDS scores between the two groups were statistically compared by t-test method The difference of mean BDDS scores between two groups before the operation, and six months after the operation was not statistically significant[p>0.4andp>0.4respectively]. However, mean BDDS scores one month after the operation were significantly higher in PYL group and perception of body image was worse [p = 0.01]. In early postoperative period, perception of change in body image was significantly worse in the PYL group. However, in late postoperative period, there were no significant differences between the two groups of patients. For these reasons, we consider that the changes in body image should not be a determining factor for selecting the surgical approach