Clinical evaluation of low vision and central foveal thickness in highly myopic cataract eyes after phacoemulsification / 国际眼科杂志(Guoji Yanke Zazhi)

measured by OCT 1 and 3mo after surgery. Chi-square test was used to compare preoperative and postoperative BCVA. Pearsion’s correlation was used to evaluate relationship between postoperative BCVA and central foveal thickness.RESULTS:The ratio of BCVA<0. 05 was 30%,14%, 11%and 7% respectively for per-operation, 1wk, 1 and 3mo post - operation. After surgery, the central foveal thickness was significantly increased in group with BCVA<0. 3 comparing to group with BCVA≥0. 3. Three month post-operation, central foveal thickness was significantly decreased in both groups comparing to that in 1mo post-operation (P<0. 01). There has significant correlation between 3mo postoperative BCVA and central foveal thickness (r=-0.716, P<0.05).CONCLUSlON: ln this study, BCVA is improved after 3mo follow up. There has significant correlation between postoperative BCVA and central foveal thickness.

Correlations between optical parameters of retinal nerve fiber layer measured by optical coherence tomography and age in normal population / 中华实验眼科杂志

Background The measurement of retinal nerve fiber layer (RNFL) by Cirrus optical coherence tomography (OCT) has been applied widely in ophthalmology.However,previous assessment of RNFL is based on spatial measurement,while the evaluation based on optical characteristics of OCT can offset the shortcomings of spatial measurement in some eye diseases.Objective This study was to analyze the optical characters of RNFL measured by OCT and its correlation with age in healthy Chinese individuals.Methods Four hundred and six normal healthy subjects were collected in Shanghai Shibei Hospital from June 2011 to June 2012,with the age of 40-83 years old.Macular RNFL was unilateral imaged using a Cirrus OCT device with 5 line raster macular scan mode under the approval of Ethic Committee of Shanghai Shibei Hospital and informed consent of subjects.A customized software was used to measure RNFL optical characters,including absorbance (A value) and attenuate coefficient.The difference of the measured parameters in different genders was compared.The correlations between RNFL optical characters and age were analyzed by linear regression analysis.Results The data of 353 eyes were included in the final outcomes.The RNFL thickness,A value and attenuate coefficient were (35.1 ±4.4) μm,121.6 ±5.3 and 2.06 ±0.25,respectively.RNFL thickness and A value showed significantly negative correlations with age (r=-0.487,-0.571,both at P＜0.01) with the regression equation Y=-0.17 X+45.23 and Y=-0.24 X+ 135.82,while a positive correlation was found between the attenuate coefficient and age (r=0.368,P＜0.01) with the regression equation Y=0.01 X+1.63.RNFL thickness and A value showed weaker positive correlations with OCT signal intensity (rs =0.128,P =0.016;rs =0.284,P＜0.01),but no remarked correlation was seen between the attenuate coefficient and OCT signal intensity (rs =-0.053,P=0.319).Conclusions Age of subjects affects the parameters of OCT optical characteristics in normal populaition.Age-related RNFL change in optical characters of OCT should be considered before concluding optical parameters.

Moxifloxacin-induced Torsade De Pointes:Literature Analysis of 5 Cases / 中国药房

OBJECTIVE: To investigate the regularity and characteristics of moxifloxacin-induced torsade de pointes (TDP), and to provide reference for rational use of drugs. METHODS: A total of 5 reported cases of moxiflixacin-induced TDP in recent 10 years were analyzed retrospectively. RESULTS: Of 5 cases, 2 cases were male and 3 female with mean age of (81?7) years. 5 patients suffered from organic heart disease. The onset time of TDP by oral administration was later than that by intravenous administration. Mean QTc intervals was (567?35) ms at attach period and the time recovered to base level (18?15) h. Potassium, magnesium, and sodium were kept at normal level at attach period. CONCLUSION: Clinical physicians and pharmacists should pay attention to moxifloxacin-induced TDP.

Anticoagulation Efficacy of Warfarin:Analysis of 95 Cases / 中国药房

OBJECTIVE:To probe into the reasons behind the overanticoagulation and underanticoagulation in patients receiving warfarin.METHODS:95 patients hospitalized in our hospital from Jan.to Sept.in 2008 were analyzed in respect of patients' age,gender,weight,dosage of warfarin,international normalized ratio(INR),anticoagulation state,drug combination,etc.RESULTS:Patients' age and weight were correlated to the dosage and anticoagulative effect of warfarin,Levofloxacin was the most potent in enhancing the anticoagulative effect of warfarin.Of the 480 times of INR monitoring,the INR of 332 (69.2%) were within 2.0～3.0,and bleeding was noted in 7 cases (7.4%).CONCLUSION:The anticoagulative effect of warfarin is associated with many factors;therefore,it is urgent to tighten anticoagulative monitoring.