[Homocysteinaemia and degenerative complications in non insulin dependent diabetes mellitus]

Type 2 diabetes mellitus [non insulin-dependent diabetes mellitus: NIDDM] is known to be associated with degenerative complications. Although, the pathophysiology of such complications is well known, the role of homocysteine [Hey] is still discussed.The aim of the present study was to evaluate the relationship between the homocysteine levels and the NIDDM related complications in a group of NIDDM patients. Our study population consisted of 41 NIDDM patients including 13 subjects [G1] without complications [group controls], 17 patients [G2] with microangiopathy and 11 patients [G3] with coronary deficiency. Plasmatic homocysteine, glycemia, glycated haemoglobin [HbAIC] and lipid parameters were assessed in all patients. Our results showed that mean levels of plasmatic homocysteine were within the normal range [10.4 +/- 3.3 micro mol/l, 9.9 +/- 5.5 micro mol/l and 14.8 +/- 10.4 micro mol/l in G1, G2 and G3 respectively]. Nevertheless, moderate hyperhomocysteinaemia was found in 36% in the coronary group [G3], 17.3% in patients with microangiopathy [G2] and 7.7% in controls.These preliminary results showed that cardiovascular complications in NIDDM patients may be related to high levels of homocysteine

Evaluation du risque cardio-vasculaire chez trois population a risque

The evaluation of the cardiovascular disease risk was standardized by an european consensus. According to the plasmatic levels of fasting triglycerides and cholesterol, this risk was classified into either desirable, moderate or elevated. In the current study, we evaluate, the vascular disease level in 100 non insulin- dependent diabetics [GI], 100 hypertensive patients [GII] and 100 hypertensive non insulindependent diabetics [GIII]. These 3 study pupulations were compared to 50 age and sex matched healthy valunteers. For each patient and control, fasting triglycerides, total cholesterol, LDL cholesterol and apolipoproteins A and B were performed. The elevated vascular disease level was more increased in hypertensive diabetic group; since 35% of this patient group has an elevated vascular risk, suggesting that these patients should be vigorously followed in order to cardiovascular risk prevention