RESUMO
Studies on pre-clinical toxicity were undertaken to determine the haematological and biochemical changes after administration of alcoholic extract of leaf-stalk of P. betle in rats and mice. Acute and chronic toxicity experiments were performed on mice and rats according to WHO protocol. Different doses of plant extractive were administered for toxicity studies on short and long term basis. Haematological, biochemical profiles and enzymatic studies (transaminases and phosphatases) indicated that the drug (plant extractive) was devoid of toxicity.
Assuntos
Magnoliopsida/química , Animais , Avaliação Pré-Clínica de Medicamentos , Enzimas/metabolismo , Feminino , Rim/efeitos dos fármacos , Fígado/efeitos dos fármacos , Masculino , Camundongos , Tamanho do Órgão/efeitos dos fármacos , Extratos Vegetais/administração & dosagem , Plantas Medicinais/química , RatosRESUMO
The sizes of the anterior fontanel were measured for 110 hilly and 130 non-hilly newborns in and around the District of Darjeeling to observe for any significant difference. The mean size of the anterior fontanel for the hilly newborns was 3.35 +/- 1.07 cm and for the non-hilly newborns was 3.80 +/- 1.95 cm. There was a significant difference (p less than 0.05) between the hilly and non-hilly races. Percentile grids for the mean anterior fontanel size were calculated. This study may help to prepare a national standard for the anterior fontanel size.