RESUMO
The present study was carried out to evaluate the usefulness of Cerebrospinal fluid (CSF) Lactate dehydrogenase (LDH) isoenzymes in the diagnosis in tuberculous meningitis (TBM), pyogenic meningitis (PM), viral encephalitis (VE) and hydrocephalus (HC). A characteristic dominance of isoenzymes in cerebrospinal fluid was observed: LDH4 in TBM while LDH3 in PM. However, in VE and HC, LDH2 and LDH1 were dominant respectively. The control subjects revealed the presence of isoenzymes LDH1 and LDH2 in very low concentrations. Pattern of LDH isoenzymes in CSF may serve as a diagnostic tool to differentiate these neurological disorders.
Assuntos
Líquido Cefalorraquidiano/enzimologia , Diagnóstico Diferencial , Eletroforese em Gel de Ágar , Humanos , IsoenzimasRESUMO
Different parameters in CSF which are routinely investigated for the diagnosis and prognosis of neurological disorders do not provide confirmation to the type of neurological disorder. The rise in protein level in CSF was found to be nonspecific and estimation of glucose and chloride in CSF has lost its significance. Therefore, determination of concentration of CSF cholesterol and triglycerides may aid in the diagnosis of tuberculous meningitis, pyogenic meningitis, viral encephalitis and hydrocephalus. The mechanism by which the levels of CSF cholesterol end triglycerides are altered in neurological disorders is not known. The rise cholesterol and triglycerides levels in CSF may be due to increased activity of brain cells or by altered function of blood brain barrier.
Assuntos
Barreira Hematoencefálica/fisiologia , Humanos , Prognóstico , Valores de ReferênciaRESUMO
The mean latency and amplitude of P100 component of VEP were studied in forty three controls and eighty nine cases of thyroid dysfunction [Hypothyroid-28; Hyperthyroid-32 and probable Thyroiditis-29 (inclusive of 21 cytology proved)]. The mean latency in hypothyroid, hyperthyroid and probable thyroiditis subjects were 110.69, 111.41 and 109 m.sec in comparison to 101.91, 102.0 and 101.08 m. sec. respectively in controls (p < 0.005). The mean amplitude being 1.34, 6.34 and 2.41 microvolts in hypothyroid, hyperthyroid and probable thyroiditis subjects in comparison to 4.79, 4.16 and 4.59 microvolts respectively in controls (p < 0.005).
Assuntos
Adulto , Idoso , Biomarcadores , Doenças do Sistema Nervoso Central/diagnóstico , Potenciais Evocados Visuais , Feminino , Humanos , Hipertireoidismo/complicações , Hipotireoidismo/complicações , Masculino , Pessoa de Meia-Idade , Valores de Referência , Sensibilidade e EspecificidadeRESUMO
In recent times there have been several reports of chloramphenicol resistant enteric fever necessitating the use of other antimicrobial agents. Clinical profile of 15 chloramphenicol resistant patients of enteric fever was studied. Three such patients (20%) responded to chloramphenicol despite in vitro resistance to the drug. Hence chloramphenicol still remains the drug of first choice in enteric fever as a majority (68.4%--26 out of 38) of our bacteriologically proven enteric fever patients were cured by the drug. The remaining 12 cases responded satisfactorily to ciprofloxacin (46.7%), gentamicin (20%), and ofloxacin (13.3%). There was an increased incidence of complications among the 15 drug resistant cases as compared to 23 cases of chloramphenicol sensitive enteric fever observed during the same period.