Intracranial Langerhans Cell Histiocytosis Presenting with Dysarthria and Gait Disturbance

Langerhans cell histiocytosis (LCH) is a rare disease of the monocyte-macrophage system involving clonal proliferation of Langerhans cells. Central nervous system (CNS) involvement of LCH occurs in 10-57% of all LCH cases. This disease is known to present in two ways in the CNS: intracranial tumorous lesions or intracranial nontumorous lesions (neurodegeneration). We report here an LCH patient who developed gait disturbance and dysarthria due to neurodegenerative lesions associated with LCH.

Development of Subdural Hemorrhage in a Patient With Cerebral Venous Sinus Thrombosis

Cerebral venous sinus thrombosis is a rare type of cerebrovascular disease with highly variable clinical features. Although intracranial hemorrhage can occur in a patient with cerebral venous sinus thrombosis, the development of subdural hemorrhage has been infrequently reported. Herein we report a 49-year-old woman with cerebral venous sinus thrombosis who developed subdural hemorrhage. We presumed that the elevation of venous or capillary pressure caused by venous sinus thrombosis played an important role in the development of subdural hemorrhage.