The Clinical Characteristics of Peyronie's Disease Patients with Diabetes Mellitus / 대한남성과학회지

PURPOSE: Although several studies have attempted to identify a relationship between Peyronie's disease (PD) and associated comorbidites including diabetes mellitus (DM), little is known about the effect of DM on the natural history of PD. We investigated the clinical characteristics of PD patients with DM for understanding of this association. MATERIAL & METHODS: Patients with PD and DM (Group 1) and those with no DM (Group 2) were compared by age, duration of PD, size and location of the plaque, severity of the penile curvature, presence of pain on erection, and the severity of erectile dysfunction by IIEF-5 scores. RESULTS: There was no significant difference in mean age of patients, duration of PD and location of the plaque between Group 1 and Group 2, respectively. The rate of severe penile curvature (>60degrees) was more frequent in Group 1 (22.7% vs. 8.6%). Plaque size was significantly bigger in Group 1 than that of Group 2 (2.2+/-1.6 vs. 1.7+/-1.3 cm, p<0.05) and mean degree of penile curvature was significantly greater in Group 1 than Group 2 (31.4+/-8.7degrees vs. 24.9+/-6.6degrees, p<0.05). The rate of severe ED (IIEF-5 < or =11 score) was significantly greater in Group 1 (18.2% vs. 4.2%, p<0.05) but pain on erection was significantly greater in Group 2 (31.8% vs. 49.2%, p<0.05). CONCLUSIONS: These results suggest that the presence of DM in patients with PD exaggerates the severity of PD by affecting the size of the plaque, penile curvature and consequent erectile dysfunction.

Delayed Spontaneous Rupture of an Orthotopic Ileal Neobladder / 대한비뇨기과학회지

Orthotopic bladder replacement using detubularized ileum has become a popular form of continent urinary diversion after performing radical cystectomy for treating invasive bladder cancer. Delayed spontaneous rupture of an orthotopic ileal bladder has rarely been reported in the English literature and it has never been reported in Korea. We describe here a case of delayed spontaneous rupture of an ileal orthotopic neobladder secondary to overdistension, and this was successfully managed nonoperatively.

Male Patients with the Diagnoses of Synchronous Prostate and Breast Cancer / 대한비뇨기과학회지

Prostate cancer and male breast cancer are similar in many ways, including the potential role of steroidal hormones in their pathogenesis and shared genetic abnormalities. However, the combination of these cancers in the same patient is rare. Herein, the case of a male patient, diagnosed with synchronous prostate and breast cancers, is reported.

Extraperitoneal Laparoscopic Radical Prostatectomy: Initial Experience / 대한비뇨기과학회지

PURPOSE: To present the short-term results of an extraperitoneal laparoscopic radical prostatectomy technique. MATERIALS AND METHODS: 18 patients underwent a laparoscopic radical prostatectomy for clinical stages ranging from cT2a to cT3b, as found on MR prostate imaging. RESULTS: Our extraperitoneal laparoscopic radical prostatectomy procedure was technically successful in all 18 patients. The mean age of the patients was 65.3 years. The mean surgical time was 421 minutes. The Foley catheter was able to be removed on postoperative days 10, 14 and 20 from 7, 5 and 3 patients, respectively, and from 1 on each of the 23, 30 and 34 postoperative days. The final pathological results were 2, 6, 5, and 5 stages pT2a, pT2b, pT3a and pT3b, respectively. There was a positive surgical margin in 8 patients (44.4%). CONCLUSIONS: Our initial series of extraperitoneal laparoscopic radical prostatectomies are presented. Using an extraperitoneal approach, avoiding the peritoneal cavity, can minimize the chances of the bowel coming into contact with electrocautery, and the associated potential sequelae. The extraperitoneal laparoscopic radical prostatectomy procedure is developmental; therefore, long-term data are currently unavailable. Nevertheless, this technique could potentially be an attractive addition to the available radical prostatectomy procedures.

The Effect of Terazosin on the Histological Changes of Rat Bladder after Partial Outlet Obstruction

PURPOSE: When the bladder outlet is partially obstructed, The expression of iNOS and collagen type III is caused by ischemia of bladder. This study aimed to evaluate the hemodynamic changes and the expression of inducible nitric oxide synthase(iNOS) and collagen type III of bladder during acute stages of partial bladder outlet obstruction in female rats and conducted a research on the effect of alpha-adrenergic blocker. MATERIALS AND METHODS: Thirty mature Sprague-Dawley rats were randomly divided into three groups; 3 days(Group I), 7 days(Group II), 14 days(Group III), depending on the term of partial bladder outlet obstruction. After obstruction, each group was subdivided into the experimental groups and the control groups; terazosin(0.4 mg/kg) was administered to the experimental groups and normal saline was administered to the control groups for a week. The degree of expression of iNOS and collagen type III in bladder was investigated by immunohistochemical stain and Western blot. RESULTS: The blood flow of experimental groups showed significant increase compared to control groups(p<0.05). The expression of iNOS and collagen type III of exerimental groups was significantly decreased compared to the controls(p<0.05). CONCLUSION: This study suggests that alpha-adrenergic blocker makes increase in blood flows to bladder and may have a role of prevention from functional damage of bladder.

Pseudoepitheliomatous, Keratotic and Micaceous Balanitis / 대한비뇨기과학회지

The condition of pseudo-epitheliomatous keratotic and micaceous balanitis (PKMB) has been described as a rare, scaling, raised lesion of the glans penis, which on histological examination showed acanthosis, hyperkeratosis and pseudo-epitheliomatous hyperplasia. It was originally thought to be a benign condition. However, recent case reports suggest that PKMB has a high propensity for malignant change. Treatment by biopsy has shown that pseudo-epitheliomatous keratotic and micaceous balanitis should be determined by the severity of the disease. We report a case of PKMB in a 38-year-old man, who presented with a one year history of an eruption on the glans penis.

Testicular Rupture Due to Dog Bites / 대한남성과학회지

Dog bites are common in many countries and the most common type of animal bites. Despite the high rates, genital trauma, especially scrotal trauma, caused by dog bite is rare, with few cases reported in the literature. We report the successful treatment of testicular rupture due to dog bite. Treatment consisted of orchiectomy with surgical debriment and antibiotics. The diagnosis and management of scrotal injury caused by dog bite are discussed.