The recent research progress of chemistry of marine natural products / 药学学报

Ocean is a unique and excellent resource that provides a diverse array of intriguing natural products. Marine natural products have demonstrated significant and extremely potent biological activities and have captured the attention of natural products chemists in the past few decades. It is increasingly recognized that a wealth of fascinating natural products and novel chemical entities will play a dominant role in the discovery of useful leads for the development of pharmaceutical agents and provide useful probes to lead to breakthroughs in a variety of life-science fields. This article focused on the research progress of chemistry of marine natural products in recent five years.

Non-taxoid chemical constituents from leaves of Taxus mairei / 中国中药杂志

<p><b>OBJECTIVE</b>To study the non-taxoids in the leaves of Taxus mairei.</p><p><b>METHOD</b>The chemical constituents were isolated by chromatography and identified by spectral data.</p><p><b>RESULT</b>Five compounds, taxamairin A (1), taxamairin B (2), sciadopitysin (3), ( - ) matairesinol (4), ponasterone A (5) were isolated and identified.</p><p><b>CONCLUSION</b>Compounds 3-5 were isolated from this plant for the first time, compounds 1 and 2 were isolated from the leaves of T. mairei for the first time.</p>

Studies on chemical constituents in heartwood of Taxus cuspidata / 中国中药杂志

<p><b>OBJECTIVE</b>To study the chemical constituents in the heartwood of Taxus cuspidata.</p><p><b>METHOD</b>Silica gel column chromatography, preparative HPLC and preparative TLC were used to isolate and purify the chemical constituents; 1H- and 13C-NMR spectroscopic methods were used for structural identification.</p><p><b>RESULT</b>Ten compounds, taxinine (1), taxusin (2), beta-sitosterol (3), 1 beta-hydroxybaccatin I (4), 2alpha, 5alpha, 10beta-triacetoxy-14beta-(2'-methyl) butanoyloxy-4 (20), 11-taxadiene (5), 2alpha, 5alpha, 10beta-triacetoxy-14beta-(2'-methyl-3'-hydroxy-butanoyloxyl-4 (20), 11-taxadiene (yunnanxane) (6), 9alpha, 10beta, 13alpha-triacetoxy-5alpha-cinnamoyltaxa-4 (20), 11-diene (7), 2-deacetoxytaxinine J (8), taxezopidine G (9), 2alpha, 7beta, 9alpha, 10beta, 13alpha-pentaacetoxyl-taxa-4 (20), 11-dien-5-ol (5-decinnamoyltaxinine J) (10), were isolated and identified from the heartwood of T. cuspidata.</p><p><b>CONCLUSION</b>Three taxanes, 1 beta-hydroxybaccatin I (4), 2alpha, 5alpha, 10beta-triacetoxy-14beta-(2'-methyl-3'-hydroxy-butanoyloxy)-4 (20), 11-taxadiene (yunnanxane) (6), and 2alpha, 7beta, 9alpha, 10beta, 13alpha-pentaacetoxyltaxa-4 (20) , 11-dien-5-ol (10), were obtained from this plant for the first time.</p>

Study on chemical constituents of mangrove Acanthus ilcifolius / 中国中药杂志

<p><b>OBJECTIVE</b>To study the chemical constituents of Acanthus ilicifolius.</p><p><b>METHOD</b>Chromatographic methods were used to isolate compounds from A. ilicifolius, and chemical and spectroscopic methods were used to elucidate the structures of the isolated compounds.</p><p><b>RESULT</b>Seven compounds, betaine (1), phenylethyl-O-beta-D-glucopyranosyl- (1-->2) -beta-D-glucopyranoside (2), phenylethyl-O-beta-D-glucopyranoside (3), acteoside (4), isoacteoside (5), benzyl-O-beta-D-glucopyranoside (6) and vanillic acid (7) were obtained.</p><p><b>CONCLUSION</b>1, 3, 6 and 7 were obtained from the genus for the first time.</p>

Studies on chemical constituents in herbs of Acanthus ilicifolius / 中国中药杂志

<p><b>OBJECTIVE</b>To study the chemical constituents of Acanthus ilicifolius.</p><p><b>METHOD</b>Chromatographic methods were used to isolate compounds from A. ilicifolius, and chemical and spectral methods were used to elucidate the structures of the isolated compounds.</p><p><b>RESULT</b>Five compounds, luteolin 7-O-beta-D-glucuronide (1), apigenin-7-O-beta-D-glucuronide (2), methylapigenin-7-O-beta-D-glucuronate (3), uridine (4) and uracil (5) were obtained.</p><p><b>CONCLUSION</b>1, 4 and 5 were obtained from the genus for the first time.</p>