Interferon-gamma and interleukin-10 levels in serum and saliva are related to different types of oral lichen planus / 中国组织工程研究

Abstract BACKGROUND: Many cytokines can be detected in saliva and serum, and have more clinical significance in the diagnosis, prognosis and treatment of oral mucosa disease. OBJECTIVE: To compare the interferon-γ and interleukin-10 levels in serum and saliva of patients with different types of oral lichen planus and to explore the feasibility of saliva samples as a substitute of blood samples to study the interferon-γ and interleukin-10 levels in serum and saliva. METHODS:Totaly 45 patients with oral lichen planus admitted at the Department of Periodontology, the Stomatological Hospital of Jiamusi University from January to July 2014 were enroled, including 15 cases of erosion type (erosion group), 15 cases of congestive erythema (congestive erythema group) and 15 cases of reticulate type (reticulate group). Another 15 healthy controls admitted for physical examination at the Department of Physical Examination, the Stomatological Hospital of Jiamusi University were enroled as controls. ELISA method was used to detect the interferon-γ and interleukin-10 levels in serum and saliva in the four groups. RESULTS AND CONCLUSION: Compared with the control group, the interferon-γ levels in serum and saliva were lower in the other three groups (P < 0.01), while there were significant differences in the interferon-γ level among the patients with different types of oral lichen planus (P < 0.01). The interleukin-10 levels in serum and saliva were significantly higher in the erosion group and congestive erythema group than those in the control group (P < 0.01 orP < 0.05) and reticulate groupP < 0.01 orP < 0.05). Experimental findings suggest that the levels of interferon-γ and interleukin-10 in serum and saliva are highly correlated in patients with different types of oral lichen planus, and saliva samples can be instead of blood samples to detect the levels of interferon-γ and interleukin-10 in patients with oral lichen planus.

Investigation on Whole Blood Lead Levels in 2956 Children of 1/12～13 Years old in Wenzhou / 医学研究杂志

Objective To Inves tigate the blood lead levels of children of 1/12～13 years old in Wenzhou and early diagnose lead poisoning in them.Methods The whole blood lead levels of 2956 children aged 1/12～13 years were determined by atom absorbspectral analysis.Results The mean of all blood lead levels was(63.11?30.17)?g/L (2037 boys were 65.55?31.23?g/L,919 girls were 57.72?26.78?g/L),318 children(10.77%) were with a blood lead ≥100?g/L(259 boys,59 girls).The prevalence of lead poisoning in boys(12.7%)as higher than those in girls 6.4%(?~2=18.99,P