Deposed Queen Yoon Might Have Suffered From Bipolar Disorder / 신경정신의학

Deposed Queen Yoon was sentenced to death by her husband, King Seongjong, on account of extreme jealousy and inappropriate behaviors. It remains unclear whether her unusual behavior resulted from a psychiatric disorder. In this study, we addressed the issue of whether deposed Queen Yoon suffered from bipolar disorder. We reviewed Seongjong Sillok (Veritable Records of King Seongjong), Joseon Wangjo Sillok (Veritable Records of the Joseon Dynasty), and the available literature on deposed Queen Yoon. A review of the literature showed that deposed Queen Yoon might have experienced depressive and manic episodes. Her symptoms of episodic course, familial tendency of mood symptoms, and postpartum onset suggest that she might have suffered from bipolar disorder. Her symptoms and clinical course suggest that deposed Queen Yoon might have suffered from bipolar disorder. To the best of our knowledge, this is the first report suggesting that deposed Queen Yoon might have suffered from bipolar disorder.

Deposed Queen Yoon Might Have Suffered From Bipolar Disorder / 신경정신의학

Deposed Queen Yoon was sentenced to death by her husband, King Seongjong, on account of extreme jealousy and inappropriate behaviors. It remains unclear whether her unusual behavior resulted from a psychiatric disorder. In this study, we addressed the issue of whether deposed Queen Yoon suffered from bipolar disorder. We reviewed Seongjong Sillok (Veritable Records of King Seongjong), Joseon Wangjo Sillok (Veritable Records of the Joseon Dynasty), and the available literature on deposed Queen Yoon. A review of the literature showed that deposed Queen Yoon might have experienced depressive and manic episodes. Her symptoms of episodic course, familial tendency of mood symptoms, and postpartum onset suggest that she might have suffered from bipolar disorder. Her symptoms and clinical course suggest that deposed Queen Yoon might have suffered from bipolar disorder. To the best of our knowledge, this is the first report suggesting that deposed Queen Yoon might have suffered from bipolar disorder.

Developing and Clinical Application of a Smartphone Mobile Mood Chart Application in Korean for Patients with Bipolar Disorder / 신경정신의학

OBJECTIVES: The aim of this study was to develop a Korean version of a mood chart application on an Android platform. METHODS: This application is based on the traditional mood chart. Eighteen adults with DSM-5 bipolar disorder were enrolled from November 2016 to March 2017. They were asked to rate their daily mood scores and severity of irritability and impulsivity for six months. Their clinicians rated their symptom severity monthly using the Clinical Global Impression-7 (CGI-7) scale. After six months, the participants completed an anonymous questionnaire regarding their satisfaction with the application. RESULTS: Of the 18 patients, one withdrew their consent from this study and six were males (35.3%) ; their mean age was 31.71±8.56 years. The mean follow-up duration was 159.12±49.45 days and the period of application use was 143.65±52.11 days. The mean total response rate was 59.45% and the mean response rate on the same day was 43.06%. The adherence to using the application decreased significantly declined over the duration since enrollment [odds ratio (OR)=1.008, p=0.008] but tended to increase according to age (OR=0.958, p=0.002). The application mood scores were correlated significantly with the manic (β=0.307, p=0.004) and depressive (β=−0.701, p < 0.001) subscale, and the total (β=1.026, p=0.002) of the CGI-7 (linear mixed models). The majority of subjects agreed that the application helped them manage their symptoms (92.86%), stating that the application was easy to use (78.57%). CONCLUSION: This application could be a valid and useful tool to monitor the mood symptoms of patients with bipolar disorder in Korea.

The Drug Adherence and Treatment Effect of the Paliperidone Long Acting Injection / 신경정신의학

OBJECTIVES: The aim of this study was to examine the drug adherence and treatment effect of the paliperidone long acting injection (LAI) in patients with schizophrenia or other psychotic disorders. METHODS: We reviewed the medical charts of patients who were prescribed paliperidone LAI from January 2010 to April 2014. Date of each injection, last observation, and first admission after use of the drug were obtained. Kaplan-Meier survival analysis was used for calculation of drug adherence. The dose of paliperidone LAI, concurrent oral antipsychotics, and anticholinergic agent was also obtained. Antipsychotics dose was calculated as olanzapine equivalent dose. RESULTS: The drug adherence of the paliperidone LAI on day 365 was 65%. The reasons for all cause discontinuation were follow-up loss, no effect, poor insight, rejection, extrapyramidal symptom, pain, etc. A total dose of 9.1 mg of oral antipsychotics was decreased, while the dose of anticholinergic agent was increased. CONCLUSION: The drug adherence of the paliperidone LAI was 65%, which was concordant with previous studies. The dose of concurrent oral antipsychotics was increased, while the dose of anticholinergic agent was decreased.