RESUMO
The water soluble part of alcoholic extract of A. indica leaves at a dose of 200 mg/kg, p.o., exerted significant antiinflammatory activity in cotton pellet granuloma assay in rats. The extract also inhibited significantly the biochemical parameters (viz. DNA, RNA, lipid peroxide, acid phosphatase and alkaline phosphatase) studied in cotton pellet exudate.
Assuntos
Animais , Anti-Inflamatórios não Esteroides/farmacologia , Masculino , Extratos Vegetais/farmacologia , Plantas Medicinais/química , Ratos , Ratos WistarRESUMO
Disease-induced stress in a living system needs its characterization before quantification. We address this problem by studying the flow behaviour of blood of rabbits. The flow behaviour of rabbit blood, both normal and streptozotocin-induced diabetic was observed by plotting viscosity levels against known shear stress. The curves obtained from normal animals showed a curvilinear relationship between eta and tau, whereas the curves obtained from the blood of the induced diabetic animals showed a 'thixotropic' nature i.e. viscosity varies inversely with shear stress. The results obtained were (a) increased viscosity associated with increasing doses, (b) the lower the shear stress, higher was the viscosity and (c) significant variation of viscosity levels between normal and induced-diabetic rabbits observed by increased stress. The possible interpretation of the results in the light of rheological properties of blood is discussed.
Assuntos
Animais , Viscosidade Sanguínea/efeitos dos fármacos , Feminino , Masculino , Coelhos , Estresse Fisiológico/sangueRESUMO
Oral administration of alcoholic extract of leaves of O. sanctum led to marked lowering of blood sugar level in normal, glucose fed hyperglycemic and streptozotocin induced diabetic rats. Further the extract potentiated the action of exogenous insulin in normal rats. The activity of the extract was 91.55 and 70.43% of that of tolbutamide in normal and diabetic rats respectively.
Assuntos
Animais , Glicemia/metabolismo , Diabetes Mellitus Experimental/sangue , Feminino , Hipoglicemiantes/farmacologia , Masculino , Extratos Vegetais/farmacologia , Plantas Medicinais , Ratos , Tolbutamida/farmacologiaRESUMO
Effect of A. indica leaf extract on serum enzyme levels (glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, acid phosphatase and alkaline phosphatase) elevated by paracetamol in rats was studied with a view to observe any possible hepatoprotective effect of this plant. It was interesting to observe that serum enzyme levels were much elevated in paracetamol induced animals than in those receiving a combination of paracetamol and lead extract. It is stipulated that the extract treated group was protected from hepatic cell damage caused by paracetamol induction. The findings were further confirmed by histopathological study of liver.
Assuntos
Acetaminofen/farmacologia , Animais , Índia , Fígado/efeitos dos fármacos , Masculino , Extratos Vegetais/farmacologia , Plantas Medicinais , Ratos , Ratos WistarRESUMO
Oral administration of water fraction of alcoholic extract of leaves of Vinca rosea (fam. apocynaeceae) led to marked lowering of blood glucose level in normal and streptozotocin induced diabetic rats. The hypoglycemic effect of the fraction was comparable with that of tolbutamide.