RESUMO
Background:Clinical features of COVID infection are varied and sometimes non-specific. Anosmia is one such clinical feature, for which limited evidence is available.Material And Methods:Subjects were contacted via telephonic interviews and data was collected regarding their perceptions about COVID infection.Result:Prevalence of anosmia in our study was 12.8% overall but significantly more (18%) in hospitalised patients/symptomatic. More than 30% of patients were having anosmia as their first symptom. Anosmia was more in patients having co morbidities.Conclusion:Loss of smell is one of the important clinical features of COVID infection. Anosmia may be the sole or fir st symptom in COVID.
RESUMO
The present study was performed to explore the antihyperglyceamic activity of ethanolic extract of leaves of Cissus quadrangularis against alloxan induced diabetic rats. Ethanolic extract of C. quadrangularis and glyburide were administered orally in alloxan induced diabetic rats. In the acute study, the serum glucose level was estimated at 0, 2, 4, 6 and 24 h after drug administration. The subacute study involved repeated administration of the drugs for 28 days, a serum glucose level estimated at 7, 14, 21 and 28 days. In the OGTT, D-glucose (2.5 g/kg) was administered in diabetic rats half an hour after pre-treatment with EtCQ and glyburide. Serum glucose levels were estimated 30 min prior to glucose administration and at 0, 30, 60 and 120 min after glucose loading. In EtCQ (400 mg/kg), the onset was 4 h, the peak effect was 6 h but the effect waned at 24 h. In subacute study, repeated administration (once a day for 28 days) of the glyburide and EtCQ caused a significant reduction in the serum glucose level as compared to the vehicle treated group. EtCQ (400 mg/kg) treatment prevented a decrease in the body weight of the diabetic rats. In the OGTT, EtCQ (200 & 400 mg/kg) increased the glucose threshold at 30 min after the administration of glucose. The EtCQ (400 mg/kg) showed significant antihyperglyceamic activity than EtCQ (100 and 200 mg/kg). It can be concluded that ethanolic extract of C. quadrangularis has antihyperglyceamic activity.