Antiproliforative effect and HLA-DR induction of recombinant gamma interferon on cultured human keratinocytes / 대한피부과학회지

The authors investigated the antiproliferative effect and expression of HLA-DR an- tigen by recombinant gamma-interferon (r-IFN-y) on cultured human keratinocytes (KC). The results were as follows, 1. From 10l.J/ml of r-1FN-p exposure, the proliferation of KC decreased in a concentration dependent fashion. But there was little difference of antiproliferative effect above 30U/ml of r-IFN-y exposure. 2. The expression of HLA-DR antigen on KC increased in a concentration and time dependent fashion of r-IFN-p exposure. E3ut t,here was little difference of HLA-DR antigen expression on KC above 30tJ/ml and most of HLA-DR antigen were expressed within 48hr. 3. The opt,imal condition for HLA-DR antigen induction on KC by r-IFN-p was likely t,hat HLA-DR KC was observed at 48hr under the our exposure of 30U/ml of r-IFN p. 4. After 4hr exposure of 30U/ml of r-IFN-p, KC expresed HLA-BR. antigen, reaching a maximum intensity at 3 days. At, 7 days, the loss of HI A-DR KC showed over 90% of maximum intensity.

A Case of Lingual Actinomucosis / 대한피부과학회지

No abstract available.

Two Cases of Segmental Neurofibromatosis / 대한피부과학회지

We report two cases of segmental neurofibromatosis that developed in s. 33-year-old female and a 35-years-old female. The skin lesions situated on the right C3 and C4 dermatomes, and on the right C2 dermatome respectively. Biopsy specimen showed collagenous wavy fibrils among which spindle-shaped and round cells were embedded as seen in the typical neurofibroma. These cases were considered to be true segmental neurofibromstosis.

A Case of Tinea Incognito / 대한피부과학회지

We report a case of tinea incognito occurring in a 47-year-old woman who deveoped erythematous papules and scaly patches on whole body after taking corticosteroid therapy intermittently over a period of 3 months. Direct smear and culture for fungus of the lesions demonstrated hyphae and C. albicans and T. mentagrophytes, which confirms the diagnosis. The lesions disappeared three months after systemic and topical antifungal therapy.