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Mem. Inst. Oswaldo Cruz ; 110(6): 814-816, Sept. 2015. tab, graf
Artigo em Inglês | LILACS | ID: lil-763088

RESUMO

Currently, there is a trend of an increasing number of Plasmodium vivaxmalaria cases in China that are imported across its Southeast Asia border, especially in the China-Myanmar border area (CMB). To date, little is known about the genetic diversity of P. vivaxin this region. In this paper, we report the first genome sequencing of a P. vivaxisolate (CMB-1) from a vivax malaria patient in CMB. The sequencing data were aligned onto 96.43% of the P. vivaxSalvador I reference strain (Sal I) genome with 7.84-fold coverage as well as onto 98.32% of 14 Sal I chromosomes. Using the de novoassembly approach, we generated 8,541 scaffolds and assembled a total of 27.1 Mb of sequence into CMB-1 scaffolds. Furthermore, we identified all 295 known virgenes, which is the largest subtelomeric multigene family in malaria parasites. These results provide an important foundation for further research onP. vivaxpopulation genetics.


Assuntos
DNA de Protozoário/análise , Genoma de Protozoário , Plasmodium vivax/genética , Análise de Sequência de DNA , China/epidemiologia , Malária/epidemiologia , Mianmar/epidemiologia , Plasmodium vivax/isolamento & purificação
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