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1.
Journal of Central South University(Medical Sciences) ; (12): 936-939, 2006.
Artigo em Chinês | WPRIM | ID: wpr-813568

RESUMO

OBJECTIVE@#To investigate the correlation between the apoptosis of psoriatic keratinocytes (KCs) in the psoriatic lesions and patient's condition.@*METHODS@#Thirty patients with psoriasis were included. Activated caspase-3 was examined by colorimetric method in skin biopsy specimens. The apoptotic KCs were detected with terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay in skin biopsy specimens. The severities of 26 patients with psoriasis vulgaris (PV) were assessed using the PASI scoring system and the severities of psoriatic lesions.@*RESULTS@#Apoptotic indexes (AI) were higher in the pustular psoriatic lesions than those in the vulgaris psoriatic lesions (P0.05). The severities of psoriatic lesions were positively correlated to AI or the expression of activated caspase-3 in PV lesions (P<0.05).@*CONCLUSION@#The amount of apoptotic KCs may be related to varied types, stages of psoriasis, and severities of psoriatic lesions.


Assuntos
Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Apoptose , Caspase 3 , Metabolismo , Queratinócitos , Patologia , Psoríase , Diagnóstico , Patologia , Índice de Gravidade de Doença
2.
Journal of Southern Medical University ; (12): 831-836, 2006.
Artigo em Chinês | WPRIM | ID: wpr-282904

RESUMO

<p><b>OBJECTIVE</b>To survey mycoplasma infection in female urogenital tract and analyze the drug sensitivity of mycoplasma in Changsha.</p><p><b>METHODS</b>Ureaplasma urealyticum (Uu) and Mycoplasma hominis (Mh) were detected in 6566 cases of female urogenital tract infection by means of mycoplasma culture and drug sensitivity reagent kit. Sensitivity tests for 10 antibiotics were also performed.</p><p><b>RESULTS</b>A total of 2938 cases were mycoplasma-positive (positivity rate of 44.75%), including 2469 Uu-positive cases (37.6%), 52 Mh-positive cases (0.08%) and 417 cases positive for both Uu and Mh (6.35%). Josamycin, doxycycline, clarithromycin and azithromycin were more effective against Uu infection. Josamycin, doxycycline and thiamphenicol were more effective against Mh infection. Mixed infection with Uu and Mh was more resistant to most antibiotics but Josamycin and doxycycline.</p><p><b>CONCLUSION</b>The female urogenital mycoplasma infection results mainly from Uu. Compared with simple Uu or Mh infection, mixed infection with Uu and Mh has significantly greater resistance to a wider variety of drugs. Josamycin and doxycycline are the primary choice for female urogenital mycoplasma infection in Changsha.</p>


Assuntos
Adolescente , Adulto , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , China , Epidemiologia , Doxiciclina , Farmacologia , Usos Terapêuticos , Farmacorresistência Bacteriana , Josamicina , Farmacologia , Usos Terapêuticos , Testes de Sensibilidade Microbiana , Infecções por Mycoplasma , Tratamento Farmacológico , Epidemiologia , Microbiologia , Mycoplasma hominis , Infecções por Ureaplasma , Tratamento Farmacológico , Epidemiologia , Microbiologia , Ureaplasma urealyticum , Cervicite Uterina , Microbiologia
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