Relationship of hypoxia-induced factor with tumor angiogenesis in early liver metastasis in colonic cancer / 中华胃肠外科杂志

<p><b>OBJECTIVE</b>To study the relationships of hypoxia-induced factor (HIF) with tumor angiogenesis and early liver metastasis in colonic cancer.</p><p><b>METHODS</b>Thirty three cases of colon cancer undergoing radical surgery were divided into two groups according to liver metastasis or not within half a year after operation. Expressions of HIF and vascular endothelial growth factor (VEGF) were examined using immunohistochemical method and tumor microvessel density (MVD) was measured in colonic cancer specimens.</p><p><b>RESULTS</b>Fifteen cases developed early liver metastasis, while 18 did not. The positive rates of HIF and VEGF, and MVD were 86.7%, 66.7%, (57.9+/- 12.7)% respectively in the group with early liver metastasis, significantly higher than 44.4% (P< 0.05), 27.8% (P< 0.05) and (22.3+/- 10.2)% (P< 0.01) respectively in the group without early liver metastasis respectively.</p><p><b>CONCLUSION</b>HIF can promote tumor angiogenesis in colonic cancer, and is closely related with early liver metastasis.</p>

A minimally invasive approach in the treatment of complicated anal fistula through spatium intermuscular of anal sphincter / 中华胃肠外科杂志

<p><b>OBJECTIVE</b>To investigate the optimal operative approach for the complicated anal fistula.</p><p><b>METHODS</b>One hundred and ninety-two cases with complicated anal fistula were randomly divided into minimally invasive operation group (through spatium intermuscular of anal sphincter) and fistula resection group. The operation time, bleeding time during and after operation, pain lasting time, healing time of incision, area of anal scar, anal malformation and function and post operative recurrence were observed and compared between the two groups.</p><p><b>RESULTS</b>Compared to those of fistula resection group, the operative time was (36.5+/- 15.3)min, bleeding time during and after operation (2.0+/- 0.5)d, postoperative pain lasting time (1.5+/- 0.5)d, healing time of incision (18.5+/- 5.5)d in minimally invasive operation group. All were shortened (P< 0.05), and the incidence of anal malformation (5.2%, P< 0.01) and partial anal incontinence (2.1%, P< 0.01) was lower. There was no significant difference in postoperative recurrence between the two groups.</p><p><b>CONCLUSIONS</b>The minimally invasive operation through spatium in termuscular of anal sphincter is superior to fistula resection on the management of complicated fistula.</p>