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Objective To study the clearance of high risk human papillomavirus(HPV)infection among the women with normal cervical pathologic diagnosis.Methods One hundred and seventy.two HPV-positive cases with normal cervical pathologic diagnosis were enrolled in the study.The infection status of HPV was monitored during follow-up from Aug 2006 to Aug 2008.The time of HPV infection spontaneous clearance,as well as effect factors,were analyzed.Results During follow-up,there were 62.2%(107 cases,107/172) of the HPV infection cleared.The medium clearance time was 11.3 months(95% CI:10.6-16.6 months).The medium clearance time of aged<30 years,30-39 years,40-49 years and>49 years were 11.3,12.0,10.9 and 8.5 months.respectively.There were not significant difference among aged intervals (P=0.384).The virus copies of HPV-clearance cases and persistent-infection were 22.6 and 95.0,respectively.There was not significant difference between groups(P=0.061).Conclusions Most of the high risk HPV infection with normal cervical pathologic diagnosis would spontaneously cleared.Age and HPV copies may play little role in the HPV clearance.
RESUMO
Objective To explore the value of laparoscopy in the diagnosis and treatment of ectopic pregnancy.Methods Laparoscopy was performed in 342 cases suspected of having ectopic pregnancy.If the confirmative diagnosis was clarified,unilateral salpingectomy,salpingostomy,ovarian wedge resection,or cornual resection were conducted;if the diagnosis was not clearly established under laparoscope,further evaluation with dilation and curettage was given.Results Out of 342 cases,335 were confirmatively diagnosed as having ectopic pregnancy under laparoscope,333 of which were successfully treated by laparoscopy(including 3 cases of ovarian pregnancy and 3 cases of interstitial pregnancy) and 2 of which were given conversions to open surgery.Among 7 cases in which the diagnosis was not clearly established under laparoscope,1 case was diagnosed as having intrauterine pregnancy with uterine anomaly(unicornuate uteri with rudimentary horn) and was treated with cornual resection and homolateral salpingectomy,1 case was diagnosed as having intrauterine pregnancy accompanying corpus luteal rupture and was treated with enucleation of corpus lutein cyst,and other 5 cases were not found having intrauterine or ectopic pregnancy and were cured with MTX injection.The time to first flatus was 8~24 hours after laparoscopic operation in 340 cases and 24~36 hours after open surgery in 2 cases.The duration of postoperative hospital stay was 2~4 days after laparoscopy except for 5 cases of MTX therapy,and 6 days after open surgery.Conclusions Laparoscopy is valuable in the early diagnosis of ectopic pregnancy;laparoscopic operation is safe and effective in the treatment of ectopic pregnancy.