Single-cell RNA-sequencing in dermatology / 中华皮肤科杂志

Single-cell RNA sequencing (scRNA-seq) is a technique to analyze the transcriptome sequence at the single cell level. It can be used to discover new cell subtypes, reveal heterogeneity between cells, track the progression of diseases, and eventually improve the understanding of complexity of tissues, organs and organisms. At present, scRNA-seq is widely applied in the fields of tumor and embryonic development, and its application in dermatology has shown a gradual growth. This review briefly introduces technical procedures of scRNA-seq, and mainly elaborates relevant progress in dermatology.