RESUMO
Type 2 diabetes often coexists with osteoporosis, leading to a significant increase in mortality in middle-aged and elderly patients, and both place a huge burden on society. There is a "diabetic bone fragility paradox" in type 2 diabetes, a high bone mineral density and high fracture risk phenomenon. In addition, some hypoglycemic drugs can also cause abnormal bone metabolism, patients with type 2 diabetes are more likely to develop osteoporosis. However, the protection of bone in patients with diabetes is often neglected in clinical practice. Even if the diagnosis of osteoporosis is clear, long-term use of anti-osteoporosis drugs is limited due to many side effects, high cost, poor compliance and other reasons. Resistance exercise(RT) has hypoglycemic and bone protection effects and can be promoted as a non-pharmacological strategy for the early prevention and treatment of type 2 diabetes patients with osteoporosis. We reviewed the research progress of RT in the treatment of T2DM with osteoporosis from four aspects: the relationship between T2DM and bone metabolism and the related pathogenesis, the impact of RT on blood glucose and skeletal muscle quality, the mechanism of RT in reducing glucose, preventing and treating osteoporosis, and the formulation of RT protocol.