effect of different doses of finasteride on epididymis and testosterone and DHT concentrations in rats

Finasteride is a widely used in the treatment of alopecia and prostatic hyperplasia. Our study was conducted to assess the effect of different doses of Finasteride on epididymis, testosterone and dihydrotestosterone concentrations in male Sprague-Dawley rats. This is experimental study conducted where thirty male rats are divided into three groups [10 rats in each group]; high dose, low dose and control groups. During 2 months period, testosterone and DHT were being measured and at the end of the experiment, rats were killed by cervical dislocation. Weight of the organs and histopathological examination were done. DHT was found significantly reduced by finasteride administation. Testosterone was unexpectedly reduced in our study. Reduction in glandular epithelium and stromal component was clearly evident in histopathological examination of the prostate. Weights of seminal vesicles, dorsal prostate and ventral prostate were significantly decreased with finasteride administration. Sperm count and motility were not significantly changed in low-dose finasteride-treated group but there was a significant reduction in sperm counts and motility in high-dose group. Finasteride has significant effects on testosterone, DHT. Also, it can affect epididymal functions if administered in high dose. It is evident from our results that there is a need for further clarification of the relation between finasteride administration and specific parameters in epididymal functions

effect of different doses of finasteride on sperm morphology and motility and reactive oxygen species concentrations in rats

Finasteride is a widely used in the treatment of alopecia and prostatic hyperplasia. Our study was conducted to assess the effect of different doses of Finasteride on sperm morphology and motility and Reactive Oxygen Species ROS concentrations in male Sprague-Dawley rats. Material and Methods: This is experimental study t where thirty male rats are divided into three groups [10 rats in each group]; high dose, low dose and control During 2 months period, Glutathione assay was done prepared blood samples the end of the experiment; rats killed by cervical dislocation. Sperm counts and morphology were assessed. Glutathione were found to be decreased significantly with increasing dose of administered finasteride which indicate statistically significant increase in the ROS levels. On the other hand, sperm motility was negatively affected only in high dose group. Abnormal sperm forms were also significant in the high-dose group. Sperm motility and morphology were not significantly changed in low-dose finasteride-treated group. Finasteride has significant effects on ROS production. Also, it can affect sperm motility and morphology negatively in high doses. Further studies clarifying the exact site and mechanism of action underlying the effects of 5 alpha reductase inhibition on spermatogenesis are needed