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Circular RNAs (circRNAs) are covalently linked circular single-stranded RNAs, which have the characteristics like abundance,conservation, stabilization and specificity. It is demonstrated that circRNA plays an important roles in the regulation of gene expression and multiple signal pathways of diseases such as cancer, cardiovascular disease, nervous system disease and autoimmune disease. In recent years, it has been reported that circRNAs are expressed abnormally in viral infectious diseases. CircRNA is expected to be a potential biomarker for viral infectious diseases and a potential target for disease therapy. In this review we briefly introduced the research progression of the roles and mechanisms of circular RNAs in viral infectious diseases and provides the references for future study.
RESUMO
Objective To detect the infection and subtype distribution of human papillomavirus (HPV) in cervical epithelial cell line in the People's Hospital of Jinhua.Methods 26 kinds of HPV genotypes were detected by gene chip,and the infection states among all subtypes were analyzed.Results A total of 25 genotypes of HPV were identified in 984 female patients,with the positive rate of 36.89％.The top three common high-risk HPV,ranging from high to low according to positive rate were HPV-16,58 and 52.The positive rates of high-risk HPV,low-risk HPV and multiple infection rate were 25.91％,5.69％ and 5.28％,respectively.The positive rates of the age groups of 21-30 years,＞ 30-40 years and ＞ 40 years were 42.33 ％,35.23％ and 35.94％,respectively.There were significant differences among the three age groups in the detection rate of high-risk HPV,low-risk type and multiple infection rate(x2 =71.58,P ＜ 0.05).Conclusion HPV 16,58 and 52 are the main high-risk genotypes of the 984 women in our hospital.The genotyping of HPV has important significance in the prevention,treatment and etiology of cervical cancer,as well as in the study of HPV vaccine.