RESUMO
Bisazir, at a 0.5% solution induced sterility in males and at a 1.5% solution in female A. dirus. These sterilizing doses reduced P. falciparum infection in mosquitoes, however, they can still transmit malaria. It is concluded that by the concentration of 1.5 and 2.0% that induced complete sterility in males and females are not safe in sterile-male release programme for the control of A. dirus, unless all females were eliminated prior to release.
Assuntos
Animais , Animais de Laboratório , Anopheles/efeitos dos fármacos , Aziridinas/farmacologia , Azirinas/farmacologia , Cruzamentos Genéticos , Feminino , Fertilidade/efeitos dos fármacos , Masculino , Oviposição/efeitos dos fármacos , Plasmodium falciparum/crescimento & desenvolvimento , Pupa/efeitos dos fármacosRESUMO
A single dose of 45 mg of primaquine base was effective in the elimination of gametocytes of the possibly chloroquine-resistant P. falciparum in Thailand. The gametocyte counts decreased markedly within 3.5 days showing significantly difference from the control in which mostly gametocytes still remain within 11.4 days. The development of the gametocytes in A. dirus was not observed after treatment. Primaquine can be used as gametocytocide and sporontocide for falciparum malaria in Thailand if the drug is administered when matured gametocytes appeared in the peripheral blood.