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Introduction: The proportion of girls “missing” has risensharply, there are obvious moral and human concernsgenerated by such extreme manifestation of gender inequity.In India, increase in overall sex ratio shown by the 2011census is applauded at several forums. However, decline inthe child sex ratio i.e. number of girls to boys in 0-6 years agegroup fell from 927 in 2001 to 914 in 2011. It is the lowestsince independence. Haryana is among the most affected stateregarding imbalance of child sex ratio. Therefore, this studywas conducted to assess the present child sex ratio and itstrend in Agroha village of Haryana.Material and Methods: This community based cross sectionalstudy was conducted in Agroha village of Haryana. Fivehundred and fifteen mothers having children in the age groupof less than 6 years were selected for the study. The primarytool in this study was predesigned and pretested interviewschedule for recording of family and individual information.Data were analyzed by using appropriate statistical tests (viz.Proportions, Mean ± SD, Chi-square test etc.).Results: With increasing parity significant decline in child sexratio was observed. Sex Ratio for 1st birth order children was929 females per 1000 males. It fell in the 2nd birth order to 830,3rd birth order to 699, 4th birth order to 462, 5th birth order to417 and still further to only 308 for 6th birth order. There was asignificant linear relationship between adverse child sex ratioin the study population with increasing birth order.Conclusion: As masculinisation with increasing parity wasobserved in the study area, it is concluded that Haryana has yeta long way to go in her fight against declining child sex ratio.
RESUMO
Background: Good nutrition during adolescence is critical to cover the deficits suffered during childhood and should include nutrients required to meet the demands of physical and cognitive growth and development, provide adequate stores of energy for illnesses and pregnancy and prevent adult onset of nutrition-related diseases. Poorly nourished adolescent mothers are more likely to give birth to low birth weight babies, perpetuating a cycle of health problems which pass from one generation to the next. Therefore, this study was aimed to assess the nutritional status of school going adolescent girls of Agroha block of Haryana.Methods: Study area was two senior secondary and two high schools (randomly selected) of Agroha block of district Hisar (Haryana). Study design was school based cross-sectional study. Study participants were three hundred and forty-four adolescent girls studying in class 9th, 10th, 11th and 12th. Study tool was pre-designed and pre-tested questionnaire. Percentages and Chi- Square. Statistical Package for Social Sciences (SPSS) software version 20.0 was used.Results: Out of total girls, 8.72% were found to be thin followed by severely thin (0.58%). Thirteen (3.78%) girls were found to be overweight followed by obese (0.58%).Conclusions: Nutritional status of adolescent girls was found to be satisfactory.
RESUMO
Background: Diabetes mellitus is a major public health problem. It is worldwide & a major risk factor for cardiovascular diseases. Glibenclamide and Glimepiride are widely used second generation sulfonylurea antidiabetic drugs. Both Glibenclamide and Glimepiride stimulate release of insulin from pancreatic acinar cells, by blocking an ATP-sensitive potassium channel. Therefore we evaluated the effect of Glimepiride and Glibenclamide on glycosylated haemoglobin in patients of type II diabetes mellitus. Aims & Objective: (1) To find out the demographic profile of type II diabetes mellitus. (2) To find out the effect of Glimepiride and Glibenclamide on glycosylated haemoglobin (HbA1c) in type II diabetes mellitus Patients. (3) To compare the effect of Glimepiride and Glibenclamide on glycosylated haemoglobin (HbA1c) among the two study groups. Material and Methods: A prospective, randomized, open, parallel group study was carried out in patients attending OPD of Medicine department MM Institute of Medical Sciences and Research (MMIMSR), Mullana, Ambala. 50 patients were randomly assigned into groups A & group B. In Group A (n=25) Glibenclamide (5-15 mg/day) & in Group B (n=25) Glimepiride (1-6 mg/day) was administered for a period of 24 weeks. Data analyzed by Student’s “t”- test. Results: It was found that prevalence of type II diabetes mellitus is more common among the male patients There was a significant reduction in glycosylated haemoglobin score (p<0.05) in both the study groups after 24 weeks but glycosylated haemoglobin level did not differ significantly (p>0.05) between the two groups. Conclusion: Glibenclamide and Glimepiride lowered glycosylated haemoglobin to a similar degree without significant difference between the two groups.
RESUMO
Background: Diabetes mellitus is a major public health problem with many complications. The Global Burden of Diabetes Study has projected that there will be a 122% increase in the number of people with diabetes mellitus worldwide in 2025 compared to 1995. Despite the availability of new agents for the treatment of type 2 diabetes mellitus oral sulfonylureas remain a cornerstone of therapy. Glibenclamide and glimepiride are widely used sulfonylurea antidiabetic drugs. Methods: A randomized, open, parallel group study was conducted by the Department of Pharmacology in association with Department of Medicine at Maharishi Markandeshwar Institute of Medical Sciences & Research (MMIMSR), Mullana, Ambala. Total 50 patients were divided into two groups I & II. In Group I (n=25) glibenclamide (5-15 mg/day) & in Group II (n=25) glimepiride (1-6mg/day) was administered for a period of 24 weeks and data analyzed by Student’s “t”- test. Results: There was a significant improvement in the post prandial blood sugar score (p<0.05) in both the study groups (I&II) after 24 weeks but post prandial blood level did not differ significantly (p>0.05) between the two groups. Conclusions: Both the drugs glibenclamide and glimepiride were effectively reduced post prandial blood sugar in both the groups. But these sulfonylurea drugs lowered post prandial blood sugar to a similar degree without significant difference between the two groups.