RESUMO
Prolonged physical exercise results in transient elevations of biochemical markers of muscular damage. This study examined the effect of short-term maximal exercise on these markers, homocysteine levels [Hcy], and total antioxidant status [TAS] in trained subjects. Eighteen male football players participated in this study. Blood samples were collected 5-min before and 3-min after a 30-s Wingate test. The results indicated that plasma biochemical markers of muscle injury increased significantly after the Wingate test [P<0.05]. Moreover, significant increase of white blood Cells and their main subpopulations [i.e. monocytes, neutrophiles, and lymphocytes] [P<0.001] has been observed. Likewise, uric acid, total bilirubin, and TAS increased significantly after exercise [P<0.05]. However, Hcy levels were unaffected by the Wingate test [for 3-min post-exercise measurement]. Short-term maximal exercise [e.g. 30-s Wingate test] is of sufficient intensity and duration to increase markers of muscle damage, and TAS; but not Hcy levels. Increases in the selected enzymes probably come primarily from muscle damage, rather than liver damage. Moreover, increase of TAS confirms the Wingate test induced oxidative stress
RESUMO
Plasma cell leukemia is considered as the leukemic variant of multiple myeloma. It is a rare entity. There are two forms: a secondary one following a known myeloma, the diagnosis of which is easy, and a primary one arising without a preceding phase of multiple myeloma. The diagnosis of the latter form is more difficult, a differential diagnosis has often to be discussed with other lymphoproliferative diseases. Prognosis is poor. We report 2 cases of secondary plasma cell leukaemia diagnosed over ten years, among 59 of multiple myeloma cases. We describe the epidemiologic, clinical, biological and evolutionary characteristics