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Objective To investigate the effect of heme oxygenase-1 ( HO-1 ) on the acute radiation-induced skin injury by gene transfer.Methods Thirty-three male SD rats were randomly divided into three groups as PBS-injected group,Ad-EGFP-injeeted group and Ad-HO-1-injected group ( n =11 ).In each group,three rats were used for determining the expression of target gene and the other rats were irradiated on the buttock skin with 40 Gy electron beam generated by a linear accelerator.Immediately after irradiation,rats were administered with a subcutaneous injection of PBS,Ad-EGFP or Ad-HO-1,respectively.Subsequently,the skin reactions were measured twice a week using the semi-quantitative skin injury scale.Results The strong positive expression of HO-1 was observed in subcutaneous dermal tissue after injection of Ad-HO-1.Compared to the PBS-injected group or the Ad-EGFP-injected group,a significant mitigation of skin injury was observed in Ad-HO-1-injected mice 14 d after irradiation (q =0.000-0.030,P ＜ 0.05 ).Conclusions HO-1 could significantly mitigate radiation-induced acute skin injury and Ad-HO-1 could be used to treat radiation-induced skin injury.
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As an important tool in the research of nuclear physics,electron cyclotron stands in an essential position in tumor radiotherapy.The theory of medical microtron is introduced.The theory of medical runway microtron is expressed and its characteristics are compared with electron linear accelerator.
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KDD has an abroad application foreground in hospital,espectially in HIS,clinical asistance,detection,and diagnosis.Some research achievements has been applied in hospital diagnosing and treatment.Such aspects of KDD are discussed as manual neural network,fuzzy system evolutionary algorithms,rough set,decision tree,support vector machine,etc.[Chinese Medical Equipment Journal,2008,29(2):74-75]