Chinese medicine preparation supramolecular imprinting templates based on in vitro release characteristics of BYHW sustained-release tablet / 中国中药杂志

The study focused on the in vitro release of Buyanghuanwu (BYHW) elementary osmotic pump sustained release tablets. Its band similarity was calculated by the total quantum statistical moment. Meanwhile, in vitro release characteristics were analyzed to discuss the existence of supramolecular imprinting templates. The results show that the same imprint templates may exist in different structures of traditional Chinese medicine(TCM)'s multi-components. The BYHW sustained release tablets prepared by elementary osmotic pump can meet the objectives of "overall control, synchronous release". However, the supramolecular imprinting templates in TCM compound prescriptions should be further explored, the overall and synchronous release of different components was controlled through imprinting templates, so as to seek the more suitable sustained release preparation technology for multiple components of TCM, and make it in line with the characteristics of TCM.

Impact of overlapping functional gastrointestinal disorders on the presentation and quality of life of patients with erosive esophagitis and nonerosive reflux disease

The aim of this study was to investigate the impact of overlapping functional gastrointestinal disorder [FGID] on the quality of life of patients with nonerosive reflux disease [NERD] and erosive esophagitis [EE]. Data from patients with NERD and EE were collected between January 2009 and March 2010. These cases were further stratified into the subgroups of overlapping NERD-functional dyspepsia [FD] NERD-irritable bowel syndrome [IBS], EE-FD, EE-IBS, and NERD or EE alone according to the symptoms. All patients completed the modified Chinese GERDQ and the SF-36 questionnaires. Of the 222 enrolled patients, 96 [43.2%] had NERD and 126 [56.8%] had EE. Overlap of FGID occurred in 43.8-45.8% of the NERD patients, and in 41.3-44.4% of EE cases. The impact of overlapping FGID on patient quality of life was greater in the patients with overlapping NERD-FD compared to those with NERD alone [mean SF-36 total scores 59 vs. 72, adjusted p = 0.025] and the cases with overlapping EE-FD compared to those with EE alone [mean SF-36 total scores 53.19 vs. 73.11, adjusted p = 0.047]. There were no significant differences between the individuals with overlapping NERD/EE-IBS and those with NERD/EE alone. There was a high prevalence of overlapping FGID, with both FD and IBS, among the GERD patients. The individuals with overlapping GERD and FD had lower quality of life scores than those with GERD alone