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Acta Pharmaceutica Sinica ; (12): 797-800, 2010.
Artigo em Chinês | WPRIM | ID: wpr-354530

RESUMO

This study is to investigate the effect of ZL-004 on normal mouse and mice with leukopenia induced by chemotherapeutic agents. 5-Fluorouracil were administered intraperitoneally to mice to develop leucopenia, and the mice were treated with ZL-004. The number of peripheral leukocytes and the percentage of granulocyte in total WBC were examined. The results are that ZL-004 markedly raise peripheral blood leukocytes in the normal mice and the mice model of leukopenia. So, ZL-004 could protect mice against 5-fluorouracil damage and raise peripheral blood leukocyte. Features of bone marrow smears is myeloproliferative hyperactivity in the mice, particularly the matured granulocytic series were observed. The mechanism of ZL-004 is to act on the mouse bone marrow causing proliferation and differentiation.


Assuntos
Animais , Feminino , Masculino , Camundongos , Antineoplásicos , Farmacologia , Células da Medula Óssea , Biologia Celular , Diferenciação Celular , Proliferação de Células , Fluoruracila , Granulócitos , Biologia Celular , Contagem de Leucócitos , Leucócitos , Biologia Celular , Leucopenia , Patologia , Camundongos Endogâmicos BALB C , Estrutura Molecular , Pirrolidinonas , Química , Farmacologia , Distribuição Aleatória
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