Effects of Several Autonomic Drugs on the Responses to Electrical Stimulation of the Detrusor Muscle Strips in Amyda Japonica / 대한비뇨기과학회지

A strip of the detrusor muscle of amyda japonica was provided in a bath which contained frog-Ringer's solution and the responses to electrical stimulation were observed by means of an isotonic myograph. The effects of several autonomic drugs on the responses to electrical stimulation of the strip were examined. The following results were obtained. 1. Electrical stimulation of the isolated detrusor muscle strip elicited contraction response and the response showed two peaks at 20 and 80 Hz between 1-200 Hz stimulation frequencies. 2. The responses to electrical stimulation of the detrusor muscle strip was completely abolished in the presence of tetrodotoxin and resumed after washing the bath fluids. 3. The responses to electrical stimulation of the detrusor muscle strip were significantly reduced in the presence of atropine, guanethidine, or regitine. 4. Clonidine did not affect the contraction response to electrical stimulation of the detrusor muscle strip. These results suggest that the detrusor muscle of Amyda japonica is innervated by both cholinergic and adrenergic nerves and it contains adrenergic alpha-receptors and that presynaptic alpha-adrenoceptors known to modify inhibit the release of neurotransmitters from the nerve endings are not involved.

Effects of Several Autonomic Drugs on the Responses to Electrical Stimulation of the Detrusor Muscle Strips in Amyda Japonica / 대한비뇨기과학회지

A strip of the detrusor muscle of amyda japonica was provided in a bath which contained frog-Ringer's solution and the responses to electrical stimulation were observed by means of an isotonic myograph. The effects of several autonomic drugs on the responses to electrical stimulation of the strip were examined. The following results were obtained. 1. Electrical stimulation of the isolated detrusor muscle strip elicited contraction response and the response showed two peaks at 20 and 80 Hz between 1-200 Hz stimulation frequencies. 2. The responses to electrical stimulation of the detrusor muscle strip was completely abolished in the presence of tetrodotoxin and resumed after washing the bath fluids. 3. The responses to electrical stimulation of the detrusor muscle strip were significantly reduced in the presence of atropine, guanethidine, or regitine. 4. Clonidine did not affect the contraction response to electrical stimulation of the detrusor muscle strip. These results suggest that the detrusor muscle of Amyda japonica is innervated by both cholinergic and adrenergic nerves and it contains adrenergic alpha-receptors and that presynaptic alpha-adrenoceptors known to modify inhibit the release of neurotransmitters from the nerve endings are not involved.

Clinical Observation on the Renal Tuberculosis / 대한비뇨기과학회지

A clinical observation was made on 57 cases of renal tuberculosis who were admitted to the Department of Urology, Capital Armed Forces General Hospital during the period from January, 1977 to December, 1979. The following results were obtained. 1. The incidence of renal tuberculosig wag 7.3% of all urological in-patients and male to female ratio was 4.7:1. The most common age group was 21 to 40 years (77.2%). 2. The site of lesion showed right to left ratio of 42.1% to 38.6% and bilateral in 19,3% of cases. 3. Vesical irritability symptoms were more frequent than other symptoms and less frequent ones showed generalized symptoms in 7 cases (12.3%) and epididymitis in 6 cases (10.5%). 4. 20(35.1%) of 67 cages bad been associated with tuberculosis other than kidney or past history. Among the 20 cases, tuberculous epididymitis was found in 9 cases (15.8%), pulmonary tubercu1osis in 6 cases (10.5%) and prostatic tuberculosis in 2 cases (3.5%) in order 5. On the intravenous pyelogram, nonvisualization of the kidney was viewed in 22 cases (38.6%). 0ther findings were calyceal destruction in 19 cases (33. 3%) and delayed visualization in 14 cases (24.6%). The most commonly viewed ureteral and vesical abnormal findings were dilatation in 19 cases (33.3%) and reduction in bladder capacity in 18 cases(31.6%) 6. The 49 operations were performed in 37 cases of renal tuberculosis. In unilateral renal tuberculosis, nephrectomy was Jone in 21 cases (88.9%), ureteric-reimplantation in 2 cases and Boari-flap in 1 case. Conservative surgeries in bilateral renal tuberculosis were ureteric reimplantation in 4 cases, nephrostomy in 3 cases, cutaneous ureterostomy, Boari flap, ureteroileocystoplasty and calycoileoileostomy in 1 cases each other.