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Objective:To discuss the clinical efficacy of Xintong oral liquid on heart failure with syndrome of Qi deficiency， phlegm and blood stasis caused by acute myocardial infarction （AMI） and the effect on inflammatory factors. Method:One hundred patients were randomly divided into observation group （50 cases） and control group （50 cases） by random number table. Both groups got comprehensive treatment of western medicine. Patients in control group got simulated medicine of Xintong oral liquid， 20 mL/time， 3 times/day. Patients in observation group got Xintong oral liquid， 20 mL/time， 3 times/day. The treatment lasted for 4 weeks. Before the treatment， and at the second week and forth week after treatment， levels of cardiac troponin I （cTnI）， cardiac troponin T （cTnT）， heart type fatty acid binding protein （H-FABP）， left ventricular ejection fraction （LVEF）， cardiac output （CO）， cardiac output per stroke （SV） and left ventricular end diastolic diameter （LVEDd）， N-terminal B-type natriuretic peptide （NT-proBNP）， lipoprotein phospholipase A2 （Lp-PLA2）， high sensitive C-reactive protein （hs-CRP）， interleukin-6 （IL-6） and tumor necrosis factor-α （TNF-α） were detected. The 6-minute walking test was performed to record the 6-minute walking distance and the ratio of 6 min walking distance to estimated value. Scores of traditional Chinese medicine （TCM） syndromes， minnesota Heart Failure quality of life questionnaire （MLHFQ） and Killip classification of cardiac function were recorded. During the 2 months' follow-up， adverse cardiovascular events （MACE） were recorded， and the safety was evaluated. Result:At the second and fourth week， levels of cTnI， cTnT， H-FABP， NT-proBNP， Lp-PLA2， hs-CRP， IL-6 and TNF-α were lower than those in control group （P<0.01）， and levels of LVEF， CO and SV were higher than those in control group （P<0.05， P<0.01）. NT-proBNP was lower than control group （P<0.01）. The 6-minute walking distance and the ratio of 6-minute walking distance to estimated value were all more than those in control group （P<0.01）. Scores of TCM syndrome integral， MLHFQ， Killip heart function grading were lower than those in control group （P<0.05， P<0.01）. Cumulative incidence of MACE was 12.0% （6/50）， which was lower than 28.0% （14/50） in control group （χ2=4.251， P<0.05）. Levels of Lp-PLA2， hs-CRP， IL-6 and TNF-α in observation group were lower those in control group （P<0.01）.And there was no adverse reactions related to Xintong oral liquid. Conclusion:Based on the comprehensive treatment of Western medicine， Xintong oral liquid can reduce the degree of myocardial injury， protect myocardium， improve cardiac function， reduce inflammatory reaction， reduce the occurrence of mace， effectively control clinical symptoms， and improve exercise tolerance and quality of life.
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Objective To evaluate choroidal thickness (CT) in healthy and primary open-angle glaucoma (POAG) eyes using deep-range imaging optical coherence tomography (DRI-OCT) and to analyze the relationship between choroidal thickness and glaucoma.Methods Totally 140 patients (216 eyes) with POAG were selected as glaucoma group,and 67 patients (106 eyes) with normal eyes as normal group.The optical coherence tomography produced by Japanese company (Topcon) was used to detect CT in both groups.The association between CT and potential confounding variables including age,axial length,central corneal thickness,systolic pressure,diastolic pressure,systolic perfusion pressure,diastolic perfusion pressure,intraocular pressure,and visual field defects were examined by using univariable and multivariable regression analyses.Results The age,axial length,systolic blood pressure and systolic blood pressure of the glaucoma group were all higher than those of the normal group (all P ＜0.05),and the subjects in the glaucoma group had more severe visual field damage,and the difference of visual field defect was statistically significant (P ＜ 0.001).There was no significant difference in corneal thickness,diastolic blood pressure,intraocular pressure and diastolic perfusion pressure between the two groups (all P ＞ 0.05).The CT was (157.70 ± 48.54) μm in the glaucoma group,and (179.9 ± 36.1) μm in the normal group,respectively,and the difference was statistically significant (P ＜ 0.001).Uninitiated regression analysis showed that CT was negatively correlated with age,axial length and glaucoma (all P ＜ 0.05).Multivariate regression analysis showed that there was no significant difference in CT between glaucoma group and normal group when the length of the age and the axis of the eye were corrected (P =0.216),and moreover,there was also no association between glaucoma severity and CT.Conclusion Glaucoma is not associated with CT measured using DRI-OCT;however,older age and longer axial length were associated with thinner CT,so CT cannot be used as a marker for diagnosing POAG and assessing the condition of the disease.