Research progress on animal model and potential therapeutic strategy in intracere-bral hemo rrhage / 药学实践杂志

Intracerebral hemorrhage (ICH) refers to bleeding within the brain parenchyma due to the rupture of blood vessels ,and is a highly lethal stroke subtype ,accounting for nearly 10%-15% of all strokes .The morbidity and mortality of ICH are very high and its pathophysiological mechanisms are currently not fully understood .Therefore ,based on current clini-cal evidence-based medicine ,there is no definite and effective medical treatment that can improve the prognosis and survival of patients available yet .As an important tool for basic research ,the development and application of the ICH animal model pro-moted the understanding of the pathophysiological mechanisms and molecular mechanisms leading to brain injury by ICH .Re-cently ,the ICH animal model studies contributed to a number of proposed potential therapeutic strategies ,such as the inhibi-tion of thrombin and the reduction of pro-inflammatory pathways .In addition ,recent research of stem cells suggested that cell transplantation therapy for the treatment of ICH may also have good prospects .In this review ,we discuss the development and application of animal models for studies on ICH and the advances regarding the potential therapeutic strategies for ICH .

Analysis of risk factors related to the pathogenesis of urolithiasis of migrant workers in Zhongshan City / 中国基层医药

Objective To explore the risk factors of urolithiasis incidence of migrant workers in Zhongshan,in order to provide the scientific evidence for preventing urolithiasis.Methods 1 630 workshop migrant workers and 1630 office white collar workers were selected as the subjects of this study.The questionnaire was conducted according to the age,gender,genetic factors,occupation,past illness factors,living environment,work environment factors,diet habit,the habit of drinking water survey,B ultrasound examination,the detection of blood uric acid.Results The incidence rate of urolithiasis was 6.53％,the incidence rate of workshop migrant workers was 8.28％,which was significantly higher than that of white collar 4.72％ (x2 =16.972,P ＜0.01).Conclusion Work environment,eating habits,drinking habits,smoking and sweating are related risk factors of urolithiasis.