RESUMO
PURPOSE: This study analyzed the expression of HLA-DR and DQ genotypes and anti-thyroid autoantibodies[anti-thyroid peroxidase (TPO) and anti-thyroglobulin (TG) antibodies] in Korean patients with type 1 diabetes (T1DM) to investigate the susceptible HLA alleles to T1DM in Korea and the prevalence of thyroid autoantibodies and their significance for the development of thyroid disorders. METHODS: A total of 59 Korean patients with type 1 diabetes[26 males, median age 13.7 years (range 5.7-29.9 years), diabetes duration 7.6 years (-1.7-22.5 years) ] were enrolled in this study, and 200 healthy Koreans without a family history of diabetes were selected as a normal control for the comparison of HLA genotypes. Seventeen patients with anti-TPO or anti-TG were followed [median duration 3.96 years (1 day-10.7 years) ] with measurement of anti-TPO, anti-TG, T3, T4 or free T4, TSH levels and physical examinations. HLA-DR and DQ genotyping were done by PCR-SSO, PCR- SSCP, PCR-RFLP and PCR-SSP methods. RESULTS: HLA analysis showed higher frequencies of HLA-DRB1*0301, *090102 and DQB1 *0201, *030302 alleles, DRB1*0301/*090102, *090102/*090102 and DQB1 *0201/*030302, *030302/*030302, *0201/*0302 genotypes in T1DM patients compared to controls (Pc 0.05). CONCLUSION: We thought this unique HLA-DR, DQ allele distribution might be an important factor for the low incidence of T1DM in Korea. And a high prevalence of thyroid autoantibodies in these populations suggests examinations of thyroid antibodies should be performed regularly. Optimal age for the initial screening and the frequency of re-screening for associated thyroid autoimmune diseases in T1DM remains to be determined through prospective follow-up.
Assuntos
Humanos , Masculino , Idade de Início , Alelos , Anticorpos , Autoanticorpos , Doenças Autoimunes , Autoimunidade , Seguimentos , Genótipo , Antígenos HLA-DR , Hipotireoidismo , Incidência , Coreia (Geográfico) , Leucócitos , Programas de Rastreamento , Peroxidase , Exame Físico , Polimorfismo Conformacional de Fita Simples , Prevalência , Estudos Prospectivos , Glândula TireoideRESUMO
Hemorrhagic shock and encephalopathy syndrome (HSES) is a sudden-onset symptom complex that in-volves multisystem failure and includes encephalopathy, shock, coma, convulsions, prerenal azotemia, hepatic dysfunction, and bleeding coagulopathy and progressive thrombocytopenia in previously healthy infants and children. Its radiologic findings have rarely been reported, and it has not been described in Korea. We present a case of clinically diagnosed HSES, and include the CT and MRI findings.