Investigation of underreporting of death monitoring in Xi’an city, 2018-2020 / 西安交通大学学报(医学版)

【Objective】 To evaluate the underreporting of death cases and related factors in disease surveillance system of Xi’an. 【Methods】 Multi-stage cluster random sampling was used, and 733 villages (neighborhood committees) were selected from 44 townships or streets in Xi’an. All the death cases of the residents in the sampled areas from 2018 to 2020 were collected through a variety of channels and checked with those registered in the Disease Surveillance System. Then the missing cases were investigated and verified. The underreporting rate was calculated, the Excel software was applied for statistical processing and Chi square analysis, and the related factors of underreporting were analyzed by using Logistic regression method. 【Results】 A total of 37650 death cases were investigated from 2018 to 2020; the average mortality was 650.59/105, and 2 901 cases were underreported. From 2018 to 2020, the underreporting rate was 9.89%, 6.95%, and 6.24%, respectively (χ2=133.525, P<0.001), with the average underreporting rate of 7.71%. The underreporting rate in the 44 sampled areas ranged from 0.90% to 42.07%. Multivariate Logistic regression analysis showed that compared with that in rural areas (9.87%), the underreporting rate was lower in urban areas (5.91%, OR=0.567, 95% CI:0.525-0.613), and higher in children under 5 years old (31.20%, OR=5.494, 95% CI:3.732-8.090) and people aged 15-44 years old (11.85%, OR=1.541, 95% CI:1.284-1.846) compared to people over 65 years old (7.44%), and higher in 2018 (9.89%, OR=1.702, 95% CI:1.551-1.869) and 2019 (6.95%, OR=1.148, 95% CI:1.038-1.271) compared to the year 2020 (6.24%). There were 2901 cases reported missing, and the proportion of those who died at home was the highest (81.39%). Underreporting of death more easily occurred in heart diseases (36.80%) and cerebrovascular diseases (27.08%) than others. 【Conclusion】 The reporting completeness of disease surveillance system increased in Xi’an. The overall underreporting rate of death causes decreased with year from 2018 to 2020. The underreporting rates in age group under 5 years old and in rural population were still high. Therefore, the reporting and management of death information should still be strengthened to minimize the underreporting rate.

The relationship between PCT,CRP and BNP levels in peripheral blood of patients with sepsis and cTn I and its clinical significance / 国际检验医学杂志

Objective To investigate the relationship between serum PCT,CRP,BNP and cardiac troponin I (cTnI)and its clinical significance in patients with sepsis.Methods 112 patients with sepsis treated in our hospital were collected.Patients were divided into sepsis,severe sepsis and septic shock groups according to their degree of illness.The serum levels of cTnI and cTnI were measured in peripheral blood samples of pa-tients with sepsis,severe sepsis and sepsis shock.To analyze the correlation between serum cTnI and cTn I in patients with sepsis.The levels of BNP and cTnI were significantly higher in septic shock group than in severe sepsis group.The difference was statistically significant(P<0.01),and that in severe sepsis group was signif-icantly higher than that in sepsis group(P<0.01).The results of correlation analysis showed that there was a positive correlation between serum PCT,BNP,CRP and cTnI levels,but the correlation was PCT(r =0.831)>BNP(r=0.456)>CRP(r=0.287).Results Conclusion cTnI and serum PCT,CRP,BNP are in the serum of the patients.With the exacerbation of sepsis patients,there will be more significant myocardial injury symptoms.

Correlation between chronic hepatitis B and serum triglyceride and cholesterol levels / 中华传染病杂志

Objective To investigate the relationship between various stages of chronic hepatitis B virus (HBV) infection and lipid metabolism and its influencing factors.Methods Seventy-two cases of chronic hepatitis B (CHB),40 cases of liver cirrhosis and 17 cases of hepatocellular carcinoma (HCC) were enrolled.One-way ANOVA analyses were used to compare age,gender,liver function,lipid metabolism,and HBV DNA levels of each group.Pearson correlation analysis was used to study the correlation between HBV DNA and lipid metabolism.Binary Logistic regression analyses were performed to explore the risk factors of cirrhosis and HCC in patients with CHB.Results Differences of age,alanine aminotransferase (ALT),albumin (Alb),triglyceride (TG),and cholesterol(CHO) among the three groups (CHB group,cirrhosis group and HCC group) were statistically significant (all P＜0.05).TG levels in cirrhosis and HCC groups were (-0.061± 0.234)lg mmol/L and (-0.061±0.253) lg mmol/L,respectively,which were both significantly lower than that of the CHB group (0.116±0.182) lg mmol/L (F=11.466,P=0.000).CHO level in cirrhosis group was (0.460±0.333) lg mmol/L,which was lower than that in CHB group (0.586±0.101) lg mmol/L (F=4.892,P=0.009).The HBV DNA levels inversely correlated with TG and CHO levels in CHB group (r=-0.266,P=0.024; r=-0.309,P=0.008,respectively).The HBV DNA levels of cirrhosis and HCC patients positively correlated with ALT levels (r=0.355,P =0.007).Old age (OR=1.096,95％CI:1.025-1.172),low Alb (OR=0.000,95％CI:0.000-0.000),and low levels of ALT (OR=0.128,95％CI:0.026-0.641) were risk factors for development of cirrhosis and HCC in CHB patients (all P＜0.05).Conclusions With the progression of liver injuries,TG and CHO levels are reduced.Further studies of correlation between risk factors for the development of cirrhosis and HCC and lipid metabolism in CHB patients are needed.

Analysis of Death Cause of Children between New Born and Fourteen Years of Age from 2005 to 2007 in Xi'an City / 中国慢性病预防与控制

Objective To investigate the characteristic of death in children between the new born and fourteen years of age in Xi'an City. Methods Surveillance data on resident death from 2005 to 2007 in Xi'an City was analyzed, classified the death cause with ICD-10. Results The average annual mortality rate in children between new born and fourteen years of age in our city was 97.91/100 000 (accounted for 3.1% of the total death), mortality rate in boys (114.39/100 000) was higher than that in girls (79.33/100 000), mortality rate in infants within one year of age was the highest (818.38 / 100 000), neonatal mortality rate counted for 83.65% of infant death; Injury, some diseases originated from perinatal period and congenital malformation were three main causes of children death. Conclusion Injury, some diseases originated from perinatal period and congenital malformation are three main causes of children death; Invention to injury and premarital, maternal health care are needed.