Multicenter study on the effect of early screening skills training for autism spectrum disorders in primary care hospitals in Chengdu / 四川精神卫生

ObjectiveTo investigate effect of conducting training of autism spectrum disorder （ASD） early screening skill on improving the ability to early identify ASD of medical staffs in primary care hospitals. MethodsIn September 2021， the training of ASD early screening skills was carried out for medical staffs from 20 primary care hospitals in Chengdu. After training， the training effect was evaluated. The numbers of referrals from primary care hospitals to superior hospitals， confirmed ASD as well as their average diagnostic age of children with ASD before and after training were used as evaluation indicators. ResultsAfter training， the number of children with suspected ASD referred by primary care hospitals was more than that before training ［（16.65±11.60） vs. （3.40±2.23）， t=5.431， P<0.01］， the number of children diagnosed with ASD was more than that before training［（6.85±4.93） vs. （2.45±1.67）， t=4.171， P<0.01］， and the differences were statistically significant. As for the diagnosed age of ASD children， after training， the average age was lower than that before training ［（34.95±11.67） vs. （42.2±14.64）， t=-2.553， P=0.019］. ConclusionTraining of ASD early screening skills for medical staffs in primary care hospitals may help to improve their ability to early screening ASD children.

The relationship between the expression of IL-13 and periostin and the severity of airway remodeling in asthmatic patients / 中国医师杂志

Objective@#By detecting the expression of interleukin-13 (IL-13) and periostin in the airway of asthmatic patients, the pathological changes and pulmonary functions of airway tissues in asthmatic patients were evaluated, and the role of IL-13 and periostin airway remodeling in bronchial asthma was preliminarily explored.@*Methods@#The bronchial tissues adjacent to tumor nest were obtained from 12 patients with lung cancer complicated with bronchial asthma (asthmatic group) and 12 lung cancer patients without bronchial asthma (non-asthmatic group) after lung cancer resection. Pulmonary function was measured for all subjects before surgery. Pathological changes of airway tissues and degree of airway remodeling were assessed by hematoxylin-eosin (H&E) staining, masson′s trichrome staining, and periodic acid-silver methenamine (PASM) staining of paraffin-embedded sections. The expression of IL-13 and periostin in bronchial tissues were evaluated by immunohistochemistry.@*Results@#Values of the forced expiratory volume in 1 second of the predicted value (FEV1% pred) and FEV1/forced vital capacity (FEV1/FVC%) in asthmatic patients were significantly decreased compared with the non-asthmatic patients (P<0.05), indicating that lung function was impaired in asthmatic patients. There was more severe airway remodeling representing as thickening of basement membranes, collagen deposition, and increasing of goblet cells and fibroblasts in asthmatic patients than in non-asthmatic patients (all P<0.05). The expression of IL-13 and periostin were higher in asthmatic tissues than in non-asthmatic tissues (P<0.05). The immunohistochemical expression of IL-13 and periostin in bronchial tissues were positively correlated with the degree of airway remodeling in asthmatic patients, and the expression of IL-13 and periostin in bronchial tissues were positively correlated with each other.@*Conclusions@#The expression of IL-13 and periostin were increased in bronchial tissue in patients with asthma. They work together to promote the occurrence of airway remodeling, which eventually lead to a decline in lung function.

The relationship between the expression of IL-13 and periostin and the severity of airway remodeling in asthmatic patients / 中国医师杂志

Objective By detecting the expression of interleukin-13 (IL-13 and periostin in the airway of asthmatic patients,the pathological changes and pulmonary functions of airway tissues in asthmatic patients were evaluated,and the role of IL-13 and periostin airway remodeling in bronchial asthma was preliminarily explored.Methods The bronchial tissues adjacent to tumor nest were obtained from 12 patients with lung cancer complicated with bronchial asthma (asthmatic group) and 12 lung cancer patients without bronchial asthma (non-asthmatic group) after lung cancer resection.Pulmonary function was measured for all subjects before surgery.Pathological changes of airway tissues and degree of airway remodeling were assessed by hematoxylin-eosin (H&E) staining,masson's trichrome staining,and periodic acid-silver methenamine (PASM) staining of paraffin-embedded sections.The expression of IL-13 and periostin in bronchial tissues were evaluated by immunohistochemistry.Results Values of the forced expiratory volume in 1 second of the predicted value (FEV1％ pred) and FEV1/forced vital capacity (FEV1/FVC％) in asthmatic patients were significantly decreased compared with the non-asthmatic patients (P ＜ 0.05),indicating that lung function was impaired in asthmatic patients.There was more severe airway remodeling representing as thickening of basement membranes,collagen deposition,and increasing of goblet cells and fibroblasts in asthmatic patients than in non-asthmatic patients (all P ＜ 0.05).The expression of IL-13 and periostin were higher in asthmatic tissues than in non-asthmatic tissues (P ＜ 0.05).The immunohistochemical expression of IL-13 and periostin in bronchial tissues were positively correlated with the degree of airway remodeling in asthmatic patients,and the expression of IL-13 and periostin in bronchial tissues were positively correlated with each other.Conclusions The expression of IL-13 and periostin were increased in bronchial tissue in patients with asthma.They work together to promote the occurrence of airway remodeling,which eventually lead to a decline in lung function.