Visual function and morphological changes in the macular area of patients with type 2 diabetes mellitus after intensive insulin therapy / 中华医学杂志(英文版)

<p><b>BACKGROUND</b>Intensive insulin therapy has been found to lessen the progress of diabetic retinopathy (DR) to some extent, while it has also been implicated to be responsible for decrease of DR. We investigated visual function and morphological changes in the macular area in short-term follow-up of patients with type 2 diabetes mellitus after intensive insulin therapy.</p><p><b>METHODS</b>This was a prospective clinical study of nonproliferative DR patients (102 eyes, 120 patients) undergoing intensive insulin therapy. The Contrast Glare Tester (Takagi CGT-1000) was used to examine contrast sensitivity (CS) and Heidelberg Retina Tomograph (HRT) II and Stratus Model 3000 OCT were used to observe the changes of morphology in the macular area. Follow-up times were pre-intensive therapy, 3 and 6 months post-intensive therapy.</p><p><b>RESULTS</b>CS at low and middle frequencies was higher at 3 and 6 months post-therapy compared with pre-therapy (P < 0.05). Significant differences in CS at low frequency were found between 6 and 3 months post-therapy (P < 0.05). Macular edema index was lower in the first, second, and third rings of the macular area after intensive therapy compared with pre-therapy (P < 0.05). Compared with 3 months post-therapy, the macular edema index was lower in the first, second, and third rings of the macular area at 6 months post-therapy (P > 0.05). No significant differences in the thickness of the first, second, and third rings of the macular area were detected between 3 and 6 months post-therapy and pre-therapy (P > 0.05).</p><p><b>CONCLUSION</b>CS and macular edema indexes were significantly improved in nonproliferative diabetic retinopathy patients after intensive insulin therapy, but thickness of the macular area was unchanged.</p>

Numerical analysis of the anti-fracture intensity of packed and repaired tooth in different cavity capacities / 生物医学工程学杂志

This study was aimed to assess the stress distribution of different capacity of class I cavity after composite resin filling. A three-dimensional finite element made of the maxillary second molar was constructed by spiral CT scan technology. Based on this model, stress distribution in tooth was analyzed before and after post-core restorations with 5 different capacities of class I cavity. When the circle triangle of class I cavities being under 50N vertical pressures, the cavity capacity increased from 3.3 mm to 3.7 mm, the maximum tensile stress values of the composite resin restorations being 3 times those of normal tooth, which were 14.872 MPa, 16.682 MPa and 17.589 MPa, 17.307 MPa and17.912 MPa. Obviously, the effect of different capacities of class I cavity on the maximum stress value enduring ability of teeth was samll, but in the analysis model, the enduring ability of teeth was reduced when the molars were filled with resin.