New progress in research on enteral nutrition management in stroke patients abroad / 中国实用护理杂志

Malnutrition secondary to dysphagia in stroke patients can hinder the recovery process of patients. Enteral nutrition therapy is an effective method to improve the nutritional status of patients. However, there is still no uniform regulation in China, which can not guide medical staff to effectively implement enteral nutrition therapy. This article reviews the recent advances in enteral nutrition management in stroke patients abroad, including screening for malnutrition in stroke patients, timing and methods of enteral nutrition therapy, potential risks and precautions for treatment, in order to provide enteral nutrition for stroke patients in China. Provide a reference for treatment and management.

Clinical analysis of 118 cases adverse reactions of anti-hypertension drug / 中国基层医药

Objective To discuss the significance of the hypertension management in root level communitiesand improve patients′treatment compliance and therapeutic effects by summarizing and analyzing adverse reactionscaused by antihypertensive drugs.Methods Retrospectively summarize clinical data of 118 hypertension patients andstatistically analyzed relevant data in a classified manner.Results 43 cases of 118 patients were male,accounting for36.4%,and 75 cases were female accounting for 63.6%.Female patients were more than male patients and the ratioof male patients to female ones is 1:1.74.Patients from 50 to 69 years old were significantly more than those of otherages and account for 62.2%.The incidence rates of adverse reactions caused by calcium channel blockers(CCB),Angiotensin Ⅱ receptor antagonist(ARB),ACEI,compound preparation,diuretic and beta receptor blockers are54.1%,21.2%,13.6%,9.3%,0.9% and 0.9%.Main clinical adverse reactions were edema of lower extremity,flush,headache,lack of power,cough,etc.Conclusion The prevalence of the hypertension in females is higher thanthat in males,the prevalence of the hypertension in patients from 50 to 69 is higher than that in patients of other ages,adverse reactions caused by antihypertensive drugs are associated with the gender and age of the patients and varietyof the drugs and such drugs should be selected on a reasonable basis during hypertension treatment.

Application of attention distraction in nursing children with maxillofacial trauma / 现代临床护理

ObjectiveTo explore the effect of attention distraction in nursing children with maxillofacial trauma. Method Eighty-eight children with maxillofacial trauma were divided into control group and observation group with 44 patients in each group.Patients in the observation group was cared with attention distraction while the control group by traditional method of forced bondage.The two groups were compared in terms of wound treatment time and healing time,comfort degree and compliance of children.Results The wound treatment time and healing time in the experiment group were shorter than those in the control group.The comfort degree and compliance of children in the observation group were better than those in the control group(P<0.05).Conclusion Attention distraction for nursing children with maxillofacial trauma can improve children’s comfort and treatment compliance and shorten treatment time.

Levels of Th1/Th2 type cytokines in TNBS and OXZ colitis without or with Trichinella spiralis infection / 中华微生物学和免疫学杂志

Objective To study the levels of Th1 and Th2 type cytokines in 3-nitrobenzene sulfonate(TNBS) and oxazolone(OXZ) colitis without or with Trichinella spiralis( T. spiralis) infection. Methods Female BALB/c mice were randomly divided into 4 groups: 50% Ethanol, T. spiralis only, TNBS or OXZ,T. spiralis +TNBS or OXZ(at least 6 in each group when mice were killed). The levels of IFN-γ, IL-12,IL-4, IL-10 in colon in mice with colitis induced by TNBS or OXZ without or with T. spiralis infection 3 d and 7 d post-induction were assessed using ELISA method. Results Colonic protein levels of IFN-γand IL-12 were significantly increased 3 d and 7 d after intra-colonic injection of TNBS( P ＜0.05 ). Concurrent infection with T. spiralis prevented this rise in IFN-γand IL-12 secretion and tended to induce a rise in colonic IL-4 and IL-10 content(P ＜0. 05). The levels of IFN-γ, IL-4 and IL-10 protein in colitic mice colon with prior nematode infection on days 3 and 7 post-induction of colitis were significantly higher than that seen in colitic mice without prior nematode infection ( P ＜ 0.05 ). Conclusion T. spiralis infection significantly attenuates TNBS-induced colitis in mice. The local immunologic mechanism is that T. spiralis can down-regulate strongly Th1-type immune response of colitis and up-regulate Th2 response, Tr1-cytokines. According to the change of Th1/Th2 cytokines, prior T. spiralis infection doesn't reduce the severity of OXZ-induced colitis, but without aggravating colitis. The exactly immunologic mechanism deserve to be explored deeply.

Effects of lactate peritoneal dialysis solution on apoptosis of human peritoneal mesothelial cells,expressions of bcl-2,bax and activity of caspase-3 / 吉林大学学报(医学版)

Objective To study the effects of lactate peritoneal dialysis solution(L-PDS) with different concentrations on apoptosis of human peritoneal mesothelial cells(HPMC),the expressions of bcl-2,bax and activity of caspase-3.Methods HPMC were separated using enzyme digestion and cultivated stably in vitro.After HPMC were co-cultivated with different concentrations(1.50%,2.50%,4.25%) L-PDS,flow cytometry was used to test the apoptosis of HPMC,RT-PCR was used to observe the expressions of bcl-2 and bax,fluorometric method was used to detect the activity of caspase-3.Results Compared with control group, L-PDS could induce the apoptosis of HPMC,especially in high concentration.With the increasing of L-PDS concentration,the expression of bcl-2 mRNA decreased,the expression of bax mRNA increased,the activity of caspase3 raised.There were significant differences of the indexes mentioned above between 4.25%,2.50% L-PDS groups and control group(P0.05).Conclusion L-PDS could induce HPMC apoptosis,which may be executed by alternating of the expressions of bcl-2,bax and activating of caspase3.