Research progress of long noncoding RNA in immune tolerance in heart transplantation / 心血管康复医学杂志

Long noncoding RNA (lncRNA) exists widely in organism .It is involved in regulatory function ,including chromatin remodeling ,gene transcription ,RNA splicing and transport of proteins etc .various biological and physi—ological process ,so regulating cell proliferation ,differentiation ,apoptosis ,growth and immune response .Certain results have been achieved in gene imprinting ,cancer diseases ,nervous system disease and immune cell differentia—tion researches about lncRNA ,but there′s few researches about its regulation of immune tolerance in heart trans— plantation .The present article made a review mainly on research progress of lncRNA in immune tolerance in heart transplantation .