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Objective:To explore the effect of rhGH on apoptosis and the expression of P53 of IgA plasmocytes of intestinal wall after intestinal ischemia-reperfusion injury and the correlation between apoptosis and the expression of P53.Methods:60 Wistar rats were divided into two groups randomly:experiment group(1.33U/kg rhGH was given q.d) and control group.Each group was divided into 3 subgroups(2,4,6days,respectively).Apoptosis and the expression of P53 in IgA plasmocytes of ileal mucosal were observed.[WTH7X]Results:[WT5”XY](1)Apoptosis of IgA plasmocytes in experiment group was lower than that in control group on 2~ nd ,4~ th ,6~ th day and had statistical significance(P
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Objective:To investigate the expression of TIP30 in gastric cancer tissues and analyze its impact with angiogenesis. Methods: The expression of TIP30 and CD34-labeled mi-crovessel density (MVD)were measured by immunohistochemical staining in 52 cases of gastric carcinomas and 47cases of Para-cancer tissues. Results: the positive rate of TIP30 was 53.8% and 85.1% in cancerous tissues and para- cancer tissues, there were significant differences between them(?2=11.22,P
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Objective:To confirm the analogue of Somatostatin OCT and NC 8 12 on the colon tumor cell growth in vitro and vivo.Methods:(1)Two colon cancer cell lines HCT116,LOVO of which cell proliferation was measured with MTT were treated with different analogue of Somatostatin in vitro.(2)The nude mice were implanted s.c.with colon cancer cell line HCT116,then were injected s.c. with OCT and NC 8 12.Results:(1).Cell proliferation of HCT116 induced by Insulin was obviously inhibited by OCT or NC 8 12 at 10 -8 mol/L 24h later after the cells were incubated with them.(2)The nude mice bearing xenografts of colon cancer HCT116 were treated for 21days subcontinuously with OCT?NC 8 12?g/(kg.d)],the inhibitory effect was seen obviously.,the inhibitory effect was seen obviously.Conclusion:The Somatostatin analogues OCT and NC 8 12 can inhibit the proliferation of colon cancer cells in vitro and vivo directly.