RESUMO
Resumen: El síndrome hemofagocítico es una enfermedad infrecuente y grave caracterizada por un estado de hiperinflamación sistémica con sobreproducción de citocinas. Puede responder a causas genéticas (primario) o desencadenarse por infecciones, fármacos, neoplasias o enfermedades autoinmunes. Existen criterios diagnósticos establecidos. El tratamiento consiste en el bloqueo de la respuesta inflamatoria sistémica, asociado al tratamiento de la causa desencadenante cuando se halla. La mortalidad es alta y usualmente está en relación a la causa que gatilla el fenómeno. Se presenta un caso de sindrome hemofagocítico en paciente infectada por el virus de la inmunodeficiencia humana.
Abstract: Hemophagocytic syndrome is a rare and serious disease characterized by a state of systemic hyperinflammation with overproduction of cytokines. Can respond to genetic causes (primary) or be triggered by infections, drugs, tumors or autoimmune diseases. There are established diagnostic criteria. Treatment consists in blocking the inflammatory response associated with the treatment of the underlying cause when it is. Mortality is high and usually is related to the cause that triggers the phenomenon. We report a case of hemophagocytic syndrome in HIV-infected patient.
RESUMO
Erysipelothrix rhusiopathie is an immobile, not sporulated, gram positive bacillus. Man is an accidental host. Infection is acquired through wounds on contact with sick animals or carriers, their products or objects contaminated with their waste. We report a 40 years old tannery male worker, presenting in the emergency room with fever lasting one month. An echocardiogram showed a vegetation and perforation of the aortic valve with severe aortic regurgitation. Blood cultures gave growth to E. rhusiopathiae. The patient was treated with penicillin. After three weeks of treatment an aortic valve replacement with a mechanical valve was performed. At six weeks, he was discharged from the hospital.