RESUMO
Objective To investigate the relationship among the content of serum HBV-DNA and the different degree of chronic liver damage,and the marks of hepatitis B virus and to explore its value in the evaluation of therapy.Method Fluorescence quantitative PCR was used to measure the concentration of sera HBV-DNA in 113 patients infected by HBV.Results The serum HBV-DNA in mild chronic hepatitis group was the highest.In the patients with aggravating liver damage,the serum HBV-DNA concentration was decreased gradually.It was indicated that serum HBV-DNA concentration in the patients with HBeAg positive was significantly higher than that of HBeAg negative.However,there were no evident relationship among HBV-DNA concentration,ALT,AST activities and different Child's classification of cirrhosis.The patients with lower serum HBV-DNA concentration before treatment had a better outcome.The therapeutical effects were correlated with the serum of viral DNA concentrations.Conclusions The quantitative detection of serum HBV-DNA has instructive value in understanding the relationship among the clinical status of chronic hepatic disease,the duplication level of hepatitis virus and evaluating therapy.
RESUMO
Aim To study the relationship between Helicobacter pylori (H. pylori) infection and genetic factor-ABO blood group. Methods 177 cases of peptic ulcer were studied, including 127 cases with H. pylori infection in Group A and 50 cases without H. pylori infection in Group B. The percentages of ABO blood group in two groups were compared each other and were compared with that of the control group(the material of ABO blood group percentages of the people in the easten China) respectively. Results ①The percentage of blood group O in group A(53. 54％) was significantly higher than that of the control (P＜0. 01). ②No significant difference was observed between Group B and the control(P＞0.05) or Group A(P＞0. 05). Conclusion There is the relationship between H. pylori infection and blood group O.