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1.
Journal of Southern Medical University ; (12): 244-247, 2015.
Artigo em Chinês | WPRIM | ID: wpr-239204

RESUMO

<p><b>OBJECTIVE</b>To analyze the factors that affect oculomotor nerve function recovery time in patients receiving balloon embolization for oculomotor nerve palsy caused by traumatic carotid cavernous sinus fistula.</p><p><b>METHODS</b>The clinical data were collected from 87 patients undergoing balloon embolization for oculomotor nerve palsy due to traumatic carotid cavernous sinus fistula from July 2005 to July 2013 and the factors affecting oculomotor nerve function recovery time was analyzed using a self-made questionnaire.</p><p><b>RESULTS AND CONLUSION</b>Oculomotor nerve function recovery time ranged from 1 to 6 months (mean 33.32 ± 16.76 days) in these patients. Age, severity of preoperative oculomotor nerve paralysis, injury-to-treatment time, and number of balloon used were positively correlated with nerve function recovery time, and the flow volume of traumatic carotid cavernous sinus fistula was negatively correlated with the recovery time.</p>


Assuntos
Humanos , Oclusão com Balão , Fístula Carótido-Cavernosa , Nervo Oculomotor , Doenças do Nervo Oculomotor , Recuperação de Função Fisiológica
2.
Chinese Journal of Biotechnology ; (12): 582-587, 2010.
Artigo em Chinês | WPRIM | ID: wpr-292234

RESUMO

The aberrant epigenetic reprogramme is an important cause for abnormal development of nuclear transfer embryos. The objective of this study was to investigate the CpG island methylation profiles and relative expression levels of H19 gene in different tissues of cloned goat fetus. We detected liver, placenta, kidney, lung and heart in the dead cloned goat fetus and the age-matched normal goat fetus (control) by using bisulfite sequencing and real time PCR. Results indicated that methylation levels of the fifth CpG island of H19 gene in dead cloned goat fetus was significant high compared with that in the control in placenta (70% vs 49.41%, P < 0.05), and relative expression levels of H19 gene was significant low compared with that in the control (883.3 vs 1 264.5, P < 0.05). Reversely, the methylation levels was significant low compared with that in the control in lung (63.53% vs 88.24%, P < 0.05), and relative expression levels was significant high compared with that in the control (1 003.4 vs 515.5, P < 0.05). The differences of others groups were insignificant (P > 0.05). Results showed the abnormal DNA methylation proflies of H19 gene occurred in some tissues of cloned goat fetus, which affected normal expression levels of H19 gene, indicating that aberrant DNA methylation reprogramme may be one of the important factors for the death of cloned animals.


Assuntos
Animais , Feminino , Clonagem de Organismos , Ilhas de CpG , Metilação de DNA , Epigênese Genética , Feto , Metabolismo , Impressão Genômica , Cabras , Rim , Embriologia , Metabolismo , Fígado , Embriologia , Metabolismo , Pulmão , Embriologia , Metabolismo , Técnicas de Transferência Nuclear , RNA Longo não Codificante , RNA não Traduzido , Genética , Metabolismo
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