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Clinics ; 67(6): 587-590, 2012. tab
Artigo em Inglês | LILACS | ID: lil-640207

RESUMO

OBJECTIVE: This study aims to evaluate the production of interferon-gamma and interleukin-10 by stimulated peripheral blood mononuclear cells isolated from patients with supraglottic laryngeal cancer before and after surgical treatment. METHODS: Fourteen patients with advanced supraglottic laryngeal cancer were studied. Cultures of peripheral blood mononuclear cells isolated during the preoperative and late postoperative periods were stimulated with concanavalin A and Bacille Calmette-Guerin, and the supernatant concentrations of interferon-gamma and interleukin-10 were measured. RESULTS: For non-stimulated cultures, the interferon-gamma levels produced by the preoperative period and the late postoperative period cultures were lower than the levels produced by the control group cultures. The interferon-gamma levels after stimulation with concanavalin A were higher in the late postoperative period cultures than in the preoperative evaluation cultures. Stimulation with Bacille Calmette-Guerin led to the production of similar levels of interferon-gamma and interleukin-10 by all cultures; thus, stimulation increased the levels of interferon-gamma produced by both the preoperative and postoperative cultures relative to the levels produced by the corresponding unstimulated cultures. CONCLUSION: Patients with advanced supraglottic laryngeal cancer exhibit an in vitro deficiency in interferongamma secretion by mononuclear cells. Stimulated cells seem to recover this function during the postoperative period.


Assuntos
Adolescente , Adulto , Criança , Feminino , Humanos , Masculino , Adulto Jovem , Carcinoma/sangue , Interferon gama/biossíntese , /biossíntese , Neoplasias Laríngeas/sangue , Leucócitos Mononucleares/metabolismo , Estudos de Casos e Controles , Carcinoma/patologia , Concanavalina A/farmacologia , Citocinas/sangue , Interferon gama/sangue , /sangue , Neoplasias Laríngeas/patologia , Leucócitos Mononucleares/efeitos dos fármacos , Mycobacterium bovis , Mitógenos/farmacologia , Estadiamento de Neoplasias , Estatísticas não Paramétricas
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