Análisis de polimorfismos ligados a enfermedad cardiovascular en población general de Buenos Aires / Analysis of the polymorphism linked to cardiovascular disease in a general population from Buenos Aires

Atherosclerotic cardiovascular disease (CVD) is a major health problem around the world. The development of CVD is a complex process, and evidence demonstrates that family history is associated with CVD. The most common forms of CVD are believed to be multifactorial and to result from many genes, each with a small effect working alone or in combination with modifier genes or environmental factors. A large number of candidate gene associatin studies have been conducted for myocardial infarction and atherosclerotic CVD. Variants of the ACE, AGT, AGTR1, APOA5, APOE, CYP11B2, eNOS, FII, FVL, MTHFR, PA11, and genes in general population of Buenos Aires have been examined in the present study; allele frequency, genotype frequency and Hardy Weinberg equilibrium were analyzed in all cases.

Nueva variante en el polimorfismo del intrón 4 de la enzima Oxido Nítrico Sintasa endotelial (eNOS) / A new variant of the polymorphism in the fourth intron from the endothelial nitric oxide synthase enzyme

Nitric oxide (NO) derived from endothelial Nitric Oxide Synthase enzyme (eNOS) is an important mediator of the vascular function. Various polymorphisms have been described for the eNOS gene that has effects on its expression. One of the most studied markers in the eNOS gen is located in the fourth intron and is characterized by the presence of a variable number of tandemly repeated sequence of 27 base pairs. In this work we report the existence and the sequence of a new variant for these polymorphism and we hypothestize its potential role in the regulation of NO productition by eNOS.

Beneficio de la rosuvastatina en el tratamiento de la hipertensión arterial y el remodelamiento ventricular / Beneficial effects of rosuvastatin in patients with arterial hypertension and ventricular remodeling

This paper describes the beneficial effects of rosuvastatin in patients with arterial hypertension in ventricular remodeling. As a conclusion, our data supports new evidence to encourage the use of statins for the treatment of cronic arterial hypertension and venticular remodeling