RESUMO
Introduction: Lipocalin-2 as an adipokine expressed in adipose tissue has a direct relationship between systemic inflammation and insulin resistance in mice and humans. The aim of this study was to investigate the effect of progressive resistance training on serum lipocalin-2, non-HDL-c, and lipid and glycemic homeostasis in men
Materials and Methods: In this semi-experimental study, 20 healthy overweight and obese males [22.75 +/- 1.29 yr, 90.18 +/- 7.28 kg, 28.7 +/- 2.58 kg/m[2]] volunteered and were randomly assigned into the training [n=10] and the control [n=10] groups. Exercise protocol was progressive resistance training [8wk, 4d/wk, 60 min/d]. Blood samples were taken before and after exercise to evaluate serum variables. Elisa method was used to measure plasma lipocalin-2 concentration. The T-test and Pearson correlation was employed for data analysis
Results: After 8 weeks' progressive resistance training, no significant changes occurred in serum levels of lipocalin-2 [p=0.59] and blood glycaemia [p=0.53], although levels of non-HDL-c [p=0.024], triglycerides [p=0.017], total cholesterol [p=0.032] and systolic blood pressure [p=0.002] were significantly decreased. There were no significant changes in other variables. A significant positive correlation was observed between changes of lipocalin-2 with insulin resistance index and a significant negative correlation with WHR in the post exercise compared to before
Conclusion: The results of this study, confirm the relationship between the lipocalin-2 insulin resistance and central obesity [WHR], with no significant impact on lipocalin-2, although it led to a significant reduction in some serum lipid profiles