RESUMO
Background:Hypertensive disorders complicate nearly 10% of pregnancies. Hypertensive disorders are a common causeof maternal and perinatal morbidity and mortality worldwide. This study is aimed at understanding the clinic-epidemiological profile of patients with hypertension in pregnancy.Methods: A cross-sectional study of pregnant females who presented to the Obstetric clinic of Department of Obstetrics and Gynaecology, Topiwala National Medical College and BYL Nair Hospital, Mumbai from June 2011 till May 2014. All pregnant females who were in the first 20 weeks of gestation were included in the study. We collected information on their socio-demographic profile like age, race, type of residence and occupation. A detailed family history, personal history, other associated medical conditions was obtained. We also noted the anthropometric measurements and gestational age. The data thus collected was analysed in Epi Info and tabulated with frequency and percentages. Result: During the study period 300 patients satisfied our inclusion and exclusion criteria with mean age 24.61 ± 4.02 years. 96% had regular menstrual flow, 59% were multipara and 77% had gestational age between 13 and 20 weeks. Mean weight of the study subjects was 50.29 ± 9.18 kgs, mean height 160.35 ± 9.42 cms and mean BMI was 19.71 ± 4.02 kg/m2. Majority of the hypertensive patients were in the group of 29 to 32 weeks of gestational age. Severe hypertension was seen most commonly in the same group. Conclusion: Hypertension in pregnancy is one the most common cause of adverse maternal and perinatal outcome. Future studies should survey pregnant females with hypertension at multiple centres to improve our understanding of hypertension in pregnancy.
RESUMO
INTRODUCTION: Acute liver failure due to acute hepatitis E carries a high mortality. METHODS: Clinical and laboratory parameters of 42 pregnant women (median age 25.5 years) with acute liver failure due to acute hepatitis E were retrospectively analyzed. RESULTS: 22 women delivered, whereas pregnancy continued in 20 women. The maternal mortality in these two groups was similar (9/22 [41%] versus 14/20 [70%], p=0.056). However, in patients with grade I, II or III hepatic encephalopathy, delivery of fetus was associated with reduced mortality in those who delivered as against those who continued pregnancy (5/16 (31%) vs. 13/20 (65%), p=0.046). On multivariate analysis, higher grade of encephalopathy at admission was associated with risk of death (p=0.005). CONCLUSION: Mortality in pregnant women with acute liver failure with acute hepatitis E is high, especially in patients who present with higher grades of encephalopathy.