Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 3 de 3
Filtrar
Adicionar filtros








Intervalo de ano
1.
Mem. Inst. Oswaldo Cruz ; 97(5): 711-716, July 2002. ilus, tab, graf
Artigo em Inglês | LILACS | ID: lil-321197

RESUMO

A study was undertaken to search for DNA recombinant Schistosoma mansoni proteins responsible for eliciting an antibody response from the host at a very early phase after infection. A S. mansoni adult worm cDNA expression library was screened using pooled sera from baboons with four weeks of infection. Based on their specific reactivity with the S. mansoni infected sera and no reactivity when tested against the pre-infection sera from the same baboons, four clones were selected for further studies. Sequence analysis revealed that they were homologous to the S. mansoni heat shock protein 70 (hsp70). The insert sizes of the four selected clones varied from 1150 to 2006 bp. The preliminary characterization for antibody reactivity against a panel of baboon sera showed that the longest clone was the most reactive, eight out of eight acute and three out of four chronic sera reacting positively to this clone. The shortest clone was the least reactive. Our results suggest that the S. mansoni hsp70 elicits an early and strong antibody response in baboons and that antibodies to this protein can be detected in chronically infected animals. Therefore S. mansoni hsp70 may be a valid target for immunodiagnosis. However further studies are needed to identify the portion of the hsp70 that best fits the requirements for a valuable diagnostic antigen


Assuntos
Animais , DNA Complementar , Proteínas de Choque Térmico HSP70 , Papio , Esquistossomose mansoni , Anticorpos Anti-Helmínticos , Antígenos de Helmintos , Papio
2.
Mem. Inst. Oswaldo Cruz ; 87(supl.4): 261-9, 1992. tab, ilus
Artigo em Inglês | LILACS | ID: lil-125661

RESUMO

Baboons develop a syndrome, including eosinophilia and transient fever, after infection with carcariae of Schistosoma mansoni that is consistent with the human syndrome of acute schistosomiasis. Radiotelemetry can be used to follow the course of fever in infected baboons. Individual variations in intensity of disease were noted in baboons. These symptoms and signs were more closely linked to the onset of oviposition by the newly matured worms than they were to the presence of migrating schistosoma or maturing worms. The baboon is concluded to be a suitable and useful model for human acute schistosomiasis mansoni


Assuntos
Animais , Reação de Fase Aguda , Primatas/parasitologia , Esquistossomose mansoni
3.
Mem. Inst. Oswaldo Cruz ; 82(supl.4): 13-16, 1987.
Artigo em Inglês | LILACS | ID: lil-623659

RESUMO

The complex immunological relationships between schistosomes and their vertebrate hosts are considered to be conveniently divisible into four distinct, though interrelated categories: the parasite's vulnerability to, its evasion of, and its exploitation of the host's immune response, and its stimulation of the host's immune response to produce immunopathology. Some significant recent advances in the first three categories are discussed, as well as their relationships to the fourth category of immunopathology.


Assuntos
Schistosoma/fisiologia , Vertebrados/parasitologia , Doenças dos Animais/imunologia , Interações Hospedeiro-Parasita
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA