Roles and their mechanisms of neuroglobin in cerebral ischemia / 国际脑血管病杂志

Neuroglobin (Ngb) is an oxygen-carrying globin that specifically expresses in brain tissue.It is involved in energy metabolism,mitochondrial function,as well as cell survival and proliferation of signaling pathway regulation.Under physiological conditions,Ngb presents as a form of ferrous deoxy hexacoordination,which has stronger oxygen affinity.During ischemia and hypoxia,the expression of Ngb is upregulated in brain tissue and interacts through a variety of proteins of its downstream,and plays a protective role for the damaged brain tissue.

Value of QRS duration predicting response of cardiac resynchronization therapy / 中国实用内科杂志

QRS wave duration is a main method of deciding cardiac asynchrony in patients with Cardiac resynchronization therapy(CRT).But cardiac mechanical dyssynchrony was not always consistent with electrical dyssynchrony.A few patients with widened QRS wave duration had not the cardiac mechanical asynchrony,while some patients with normal QRS wave duration had cardiac mechanical asynchrony.If the cardiac mechanical dyssynchrony was determined,it would be possible to reduce the non-response of CRT.We review the role of QRS duration to predicting the prognosis of CRT and debate the effect of QRS duration to CRT.