RESUMO
Objective@#To describe the status of non-steroidal anti-inflammatory drugs (NSAIDs) use in areas with a high incidence of upper gastrointestinal cancer in China. @*Methods@#This study was based on the National Key Research and Development Program of "National Precision Medicine Cohort of Esophageal Cancer" and "Study on Identification and Prevention of High-risk Populations of Gastrointestinal Malignancies (Esophageal cancer, Gastric cancer and Colorectal cancer)" . From January 2017 to August 2018, 212 villages or communities with a high incidence of esophageal cancer or gastric cancer were selected from 12 regions in 6 provinces. A total of 35 910 residents aged between 40 and 69 years old who met the inclusion criteria and signed the informed consent were investigated and enrolled in this study. The use of NSAIDs, demographic characteristics, health-related habits, height, weight, and blood pressure were collected by the questionnaire and physical examination. The status of main NSAIDs (aspirin, acetaminophen and ibuprofen) use with the difference varying in genders, age groups and regions were analyzed by using χ2 test and Cochran-Armitage trend analysis method. @*Results@#Of 35 910 subjects, the mean age was (54.6±7.1) years old and males accounted for 43.42% (15 591). The overall prevalence of NSAIDs intake was 4.56% (1 638), but it significantly varied in different provinces (P<0.001). The overall prevalence of NSAIDs intake was 4.87% (1 750) in females, which was significantly higher than that in males 4.24% (1 524) (P<0.001). The prevalence of NSAIDs intake increased with age (P for trend <0.001). As the frequency of NSAIDs intake increased, the incidence of gastrointestinal symptoms, gastrointestinal ulcers and black stools increased (P for trend <0.05 for all). @*Conclusion@#The use of NSAIDs is prevalent in some areas with a high incidence of upper gastrointestinal cancer in China. The increased use of NSAIDs may lead to more adverse effects related to the gastrointestinal tract.
RESUMO
With the widely application of the metagenomics,the relationship between microbiota and disease has become a hot research topic.Understanding the potential association between upper gastrointestinal cancer or precancerous lesions and microbiota may play an important role in the early detection,clinical diagnosis and treatment,and prognostic evaluation of upper gastrointestinal cancer.Therefore,a literature retrieval was conducted by using PubMed,Embase and wanfang databases to summarize the latest research progress in the microbiota of upper gastrointestinal cancer,including oral,esophageal,gastric cancer and precancerous lesions.Lower microbial diversity or richness in esophageal cancer and precancerous lesions and specific prognostic biomarkers for esophageal cancer were found.Lactobacillus richness showed an increase trend during the process from gastritis to gastric cancer.This paper summarizes the progress in the research of potential biological etiology of upper gastrointestinal cancer from the perspective of metagenomics in order to provide evidence on the,prevention and control of upper gastrointestinal cancer.
RESUMO
With the widely application of the metagenomics,the relationship between microbiota and disease has become a hot research topic.Understanding the potential association between upper gastrointestinal cancer or precancerous lesions and microbiota may play an important role in the early detection,clinical diagnosis and treatment,and prognostic evaluation of upper gastrointestinal cancer.Therefore,a literature retrieval was conducted by using PubMed,Embase and wanfang databases to summarize the latest research progress in the microbiota of upper gastrointestinal cancer,including oral,esophageal,gastric cancer and precancerous lesions.Lower microbial diversity or richness in esophageal cancer and precancerous lesions and specific prognostic biomarkers for esophageal cancer were found.Lactobacillus richness showed an increase trend during the process from gastritis to gastric cancer.This paper summarizes the progress in the research of potential biological etiology of upper gastrointestinal cancer from the perspective of metagenomics in order to provide evidence on the,prevention and control of upper gastrointestinal cancer.